Positions Related to Cell Senescence

Chief Scientific Officer – Senescence - STARKAGE THERAPEUTICS

Open untilf fulfilment (last update on March 07, 2022)

SATX seeks a Chief Scientific Officer (CSO) to reinforce its organization, following their recent DeepTech label, which included €2M in non-dilutive funding. Reporting to the CEO, the CSO will lead discovery and manage characterization and validation of senescence selective and predictive markers, propose, and develop an alternate method for the depletion of senescent cells using immunotherapy. This role involves strategic leadership in R&D, as well as broad expertise in the management of early-stage research programs and directing target discovery and validation activities. The CSO is a key member of the senior leadership team and directly manages the research team of 4 (expected to double within 12-18 months) in our Discovery Labs. The CSO also actively manages current and future academic collaborations. The position is in Lille, France with a minimum of four days per week on-site, and one day remote if desired.

The Offer:

• Permanent full-time employment contract (CDI)

• Competitive salary and performance-related bonuses

• Secondary insurance (mutuelle), Tickets restaurant


If interested, please send your CV to recruitment@StarkAgeTX.com with the reference CSO-2022. Include your daytime phone number and we will contact you confidentially or reply to your email. All applications will be responded to.

More details HERE.

Scientist (m/f/d) working on epigenetics, RWTH Aachen University Hospital (Germany)

Expires on February 15, 2022

The position is initially funded for 3.5 years with a possibility for extension. It is supported by the Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center “Aging at Interfaces

Human aging is associated with specific DNA methylation changes and our group was one of the first to describe such “epigenetic clocks”. In this collaborative research project, we will make use of the population-based cohort study ActiFE-Ulm to gain further insight into how such epigenetic modifications can be used as a biomarker to discern “biological age” from “chronological age”. Targeted epigenetic clocks will be developed and correlated with clinical parameters for biological age and frailty. Furthermore, we aim for functional analysis of age-associated epigenetic modifications in iPSC models with CRISPR technology. We want to understand how age-associated DNA methylation patterns can be modified during reprogramming and differentiation. You can find further information on our research group under http://www.stemcellbiology.ukaachen.de.


We are looking for a motivated and ambitious scientist with a strong background in epigenetics, aging research, and/or stem cell biology. You should have experience in cell culture and handling of sequencing data. Experience with bioinformatics, DNA methylation data, and/or iPSC culture would be advantageous. An important part of the work will be close interaction with other members of the Collaborative Research Center “Aging at Interfaces”. You should hold a very good master (e.g. in Molecular Biology) and a very good PhD. If you do not yet hold a PhD degree, it would in principle also be possible to make a PhD within this project. Willingness for teamwork is a prerequisite. 


Your application should be send by E-mail to Prof. Dr. Dr. Wolfgang Wagner (wwagner@ukaachen.de).


The application period for the advertised position ends on 15.02.2022.


More info HERE.

Postdoctoral Scholar and Research Assistant/Associate positions, Anna Vilgelm lab at the Ohio State University (USA)

Open until fulfilment (last updated Mar 03, 2022)

Several positions are available in Vilgelm Laboratory to study how tumor senescence modulates tumor immune microenvironment and immunotherapy responses. This research aims to find novel rational therapeutic strategies to enhance anti-tumor immunity and improve immunotherapy benefits in cancer patients. Successful candidates will develop, adopt and implement cutting-edge laboratory methods, including multi-omics, automated microscopy, spectral cytometry, and complex Patient-Derived co-cultures. Select projects will require working in close collaboration with clinical oncologists and data scientists to facilitate high-impact translational discoveries.

We are seeking highly motivated individuals. A postdoctoral scholar candidate should have a recent Doctoral degree in Immunology, Cancer Biology, Bioinformatics, or closely related fields. Previous experience in cancer immunology, omics data analysis, 3D cell culture, or mouse models is desirable. Research Assistant candidates should be willing to work with mice, and prior experience in this field is a plus.

Ohio State University offers a comprehensive benefits package with a variety of options to meet your unique needs.

Application: Please email your CV to anna.vilgelm@osumc.edu



More info HERE and HERE.

Postdoctoral Research Fellow, Goel Laboratory at the Peter MacCallum Cancer Center in Melbourne, Australia

Expires on March 10, 2022

The Goel laboratory at the Peter MacCallum Cancer Centre in Melbourne, Australia is recruiting a postdoctoral scientist. The successful candidate will play a central role in our studies of therapy-induced senescence (TIS) in cancer. Dr Shom Goel is a practising clinical oncologist and laboratory scientist with expertise in cell cycle biology, cellular senescence, and cancer drug development. He has recently been awarded Australia’s prestigious Snow Medical Fellowship, which will fund his team’s studies of senescence in cancer over the next 8 years. 

New research projects in the lab include: (i) identifying novel senolytics and agents to prevent senescence escape in cancer; (ii) exploring parallels between tumour dormancy and TIS; (iii) understanding the significance of heterogeneity amongst senescent cancer cells; (iv) dissecting the contribution of key tumour suppressor proteins to the TIS Phenotype in cancers.  We employ a wide range of techniques including transgenic mouse modelling, high-throughput compound screening, CRISPR Cas9 screens, epigenomics, and single cell transcriptomics. The successful candidate must have a strong grounding in cancer biology. It is preferable that they also have experience in study of cell cycle biology, cancer epigenetics, or tumour suppressor proteins.

The Goel lab is two years old. We are dynamic team and strive to create a fun, stimulating, and rewarding work environment.  We are located just five minutes from the heart of Melbourne - a vibrant and culturally diverse city with an excellent quality of life.

Interested candidates should apply using the following link: https://petermac.mercury.com.au/ViewPosition.aspx?id=JbZb9jhRIa0=&jbc=ere
Specific questions should be addressed to Dr Goel: Shom.goel@unimelb.edu.au

Competition funded PhD project (UK Student only) in Dr. Catarina Henriques Lab, University of Sheffield (UK)

To be posted again soon

Understanding gut degeneration in ageing, one cell at a time - Deciphering the role of telomerase in multi-cellular ageing of the gut, using single-cell RNA sequencing in the zebrafish model

The overall aim of this project is to determine how the transcriptomic signatures of the different cellular components of the gut change with ageing, using telomerase mutant zebrafish as a premature model of ageing. We will take advantage of an already obtained single cell RNA sequencing data from gut tissue and aim to identify cells and potential mechanistic targets for ameliorating or preventing gut degeneration and dysfunction. We will further validate key identified targets in situ and/or in whole gut tissue, using with specialised laboratory techniques involving molecular and cellular Biology (RNA in situ, immunofluorescence, fluorescence microscopy imaging, western blotting, qPCR, senescence associated beta-galactosidase assay) as well as histopathology analysis and correlation with ageing phenotypes.

Please complete a University Postgraduate Research Application form available here: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying

Please clearly state the prospective main supervisor in the respective box and select 'Oncology & Metabolism' as the department.

Interested candidates should in the first instance contact Dr Catarina Henriques, c.m.henriques@sheffield.ac.uk


IRMB - Stem Cell and Genome Plasticity in Development and Aging, Team Leader Jean-Marc Lemaitre (INSERM U1183, Hôpital Saint-Eloi, Montpellier, France)

Open until fulfilment (last updated Dec28, 2021)

We are seeking to appoint a postdoctoral researcher to better understand the role of cellular reprogramming associated to senescence escape to cancer initiation, to identify and validate novel targetable biomarkers of cancer stem cells. The postdoc will be based in the laboratory of Dr Jean-Marc Lemaitre, Group Leader of the Team Genome and Stem Cell Plasticity in Development and Aging, and co-Director of the Institute of Regenerative Medicine and Biotherapies of Montpellier, France. This position is funded for 3 years by INCa (French National Institute of Cancer), and is available from 1st January 2022.

Jean-Marc Lemaitre’s research aims to understand the epigenetic control of senescence/aging and age-related diseases. The team demonstrated that cellular aging is reversible by reprogramming through pluripotency and developed transient reprogramming strategies in in vivo and in vitro models, to escape from senescence. Candidates must have a PhD in the biological/biomedical sciences. A significant experience in cell senescence and stem cell reprogramming, as well as skills in bioinfomatics analysis are mandatory. A second Post-Doc, will be highly appreciated. A collaboration is engaged with Marco-Mendoza Parra (partner in the INCa project), leader of the Team SySfate from Genoscope (Evry, France), to further develop system biology analysis. These studies will enable us to dissect the role of senescence escape in cancer stem cells formation by a multidimentional profiling approach integrating, transcriptomes, epigenome, chromatin domain interactions in a time dependent manner. The ultimate objective is to identify new therapeutic targets to develop npharmacologically-active drugs for tumor eradication. The postdoc will carry out independent research and will be supported by an Engineer from the team.

How to apply: Applications are invited from outstanding and highly motivated candidates for a fixed term position as postdoctoral researcher in the group of Jean-Marc Lemaitre, at the Institute of Regenerative Medicine and Biotherapies in Montpellier.

Applications will include a cover letter, CV, and the contact details of three referees should be sent,
via e-mail to Jean-Marc Lemaitre : jean-marc.lemaitre@inserm.fr

More info.

Postdoctoral Research Fellow Opening - Schafer Lab, Mayo Clinic (Minnesota, USA)

Open until fulfilment (last updated Mar 03, 2022)

The Schafer Lab at Mayo Clinic in Rochester Minnesota is seeking a Postdoctoral Fellow to participate in NIH-funded aging research. The candidate should have an interest in studying cellular senescence as a mechanism contributing to age-related systemic and brain dysfunction. Candidates with experience in advanced ‘omics’ or single cell phenotyping, including but not limited to single cell sequencing, mass cytometry, flow cytometry, or spatial profiling, are encouraged to apply. Experience with computational or bioinformatic analyses is highly desirable. Candidate should have a Ph.D., M.D., M.D./Ph.D., or equivalent doctoral degree with 0-3 years of post-Doctoral experience. Candidates should have a strong work ethic and good oral and written communication skills. Applicants should submit their CV, a cover letter containing a brief statement of how her/his expertise can contribute to the research described above and contact information for three references to: Schafer.Marissa@Mayo.edu

Additional information can be found here: https://jobs.mayoclinic.org/job/rochester/research-fellow/33647/18037092256