Positions Related to Cell Senescence

Senior Research Scientist & Postdoctoral Fellow - Stanford University School of Medicine (USA)

The Blau lab is seeking creative, highly motivated, and team-oriented  scientists to perform cutting-edge research: a Senior Research Scientist and a postdoctoral fellow to join the Blau Lab in the Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine. Successful candidates will work with a multidisciplinary and dynamic research team on neuromuscular aging, rejuvenation, and regeneration. A major focus of the lab is our recent discovery that the Prostaglandin Degrading Enzyme (15 PGDH) is a pivotal molecular determinant of muscle aging ( Palla et al. Science 2021 ) and its potential to rejuvenate multiple aged tissues.
 
The senior scientist position requires a highly accomplished and rigorous scientist with an outstanding track-record of innovation and a sustained publication record. A PhD or MD/PhD and 5+ years of postdoctoral research experience. A strong background in molecular biology, assay development, mammalian primary cell culture, transgenic mouse models, and microscopy are essential. Expertise in FACS, muscle biology, metabolism, aging, stem cell biology or regenerative medicine is desired. Excellent interpersonal, communication and writing skills are imperative. The successful candidate will have a key role in orchestrating collaborations and directing a team of creative highly motivated researchers, including postdoctoral fellows, graduate students, and research assistants.
 
The postdoctoral position requires a PhD or MD/PhD in Biological Sciences. Previous expertise and/or interest in stem cell biology, mouse models, high throughput sequencing technologies, bioinformatics, and genomics with a focus on treatments for aging and disease is desired. Ideal candidates should be scientifically rigorous, collaborative, and eager to learn about new fields and techniques.

Postdoctoral position in Cambridge, UK - Senescence in Cancer

The laboratory of Dr Daniel Munoz-Espin offers a Postdoctoral Position in the Department of Oncology at University of Cambridge. This post, funded by a CRUK Programme Foundation Award, is offered for 3 years in the first instance, with the possibility to be extended up to 5 years due to the availability of funding. Details can be found in the following links:
 
- Postdoctoral Position (RD29923). Senescence in Cancer.  https://www.jobs.cam.ac.uk/job/29923/
 
 https://www.nature.com/naturecareers/job/research-associate-senescence-in-cancer-fixed-term-university-of-cambridge-741251
 
 
Please contact Dr Daniel Munoz-Espin (dm742@cam.ac.uk) for any informal enquiries. The closing date of the advert is Sunday 27th June 2021.

Postdoctoral position in Barcelona, Spain - Computational Biologist

IRB Barcelona seeks to recruit a Postdoctoral Researcher to work on a collaborative project between the laboratories of Manuel Serrano and Núria López-Bigas at the IRB Barcelona.

We are searching for a highly motivated Postdoctoral Researcher to work on a computational biology project to understand the mechanisms behind the DNA methylation aging clocks and cellular rejuvenation.

The ideal candidate should have previous experience in epigenomics data analysis and machine learning. They will have coding experience with Python and/or R, and knowledge in data analysis. She/he should have strong analytical skills, in addition to creativity, curiosity, enthusiasm, and ability to work in a team. The candidate will have the opportunity to participate in a collaborative project between Manuel Serrano lab and Nuria Lopez-Bigas lab.

https://recruitment.irbbarcelona.org/jobs/1172348-postdoctoral-fellow-in-computational-biology-ref-pd-21-10

Postdoctoral position in Jesus Gil’s group (Imperial College, London, UK)

Applications are invited for the position of a Research Associate within the Cell Proliferation Group at the MRC London Institute of Medical Sciences (LMS). The LMS is directly funded by the Medical Research Council and associated with Imperial College. This position is funded by a grant of CRUK. We are looking for a highly motivated postdoc interested in joining our friendly and international team. The successful candidate will work in a project studying the interplay between splicing and senescence and its implications on cancer. A strong background in molecular and cellular biology and experience with animal work are required. Experience in senescence, cancer research or genetic and drug screens is important. Experience working with primary cells, familiarity with retroviral and lentiviral systems, with genetic or drug screens or with high content microscopy systems a plus.

For more information and applications:
https://www.imperial.ac.uk/jobs/description/MED02298/research-associate
 
Informal enquiries to Jesus Gil (jesus.gil@imperial.ac.uk)

Postdoctoral position in d’Adda di Fagagna’s group (Milan, Italy)


We have an immediately available opening for an experienced and motivated researcher at the postdoctoral level to study the impact of telomeric DDR inhibition with ASO in mouse models of aging and aging-related disorders.

We seek a candidate with a background in aging and/or telomere dysfunction mouse models. Also candidates with experience with the in vivo use of ASO will be considered favorably. Experience in histopathological evaluations or bioinformatics skills is a plus.


More information HERE.

Postdoctoral Research Scientist (Senescent Cell Atlas-Data Analysis)


The Babraham Institute (Cambridge, UK) is seeking an enthusiastic Postdoctoral Research Scientist to join Wolf Reik’s group in their Epigenetics Programme. 

The Postdoctoral Scientist will work on an exciting collaborative project (together with Prof. Masashi Narita and Dr. John Marioni at the CRUK Cambridge Institute) aiming to understand the heterogeneity of senescent cells using cutting edge single-cell and multi-omics datasets.

The post holder will play a central role in our research programme, analysing large and complex datasets generated by us and our collaborators using existing and novel computational methods. The post is envisaged to be largely computational but could also include working with primary mouse cells to generate multi-omics libraries for next generation sequencing. In addition to conducting his/her research in the areas outlined above, the post holder will help with training the lab’s graduate students and with other laboratory activities.

More information HERE.

Informal enquiries can be addressed to Dr Aled Parry (aled.parry@babraham.ac.uk)

Research Technician (London, UK)


The Centre for Cutaneous and Cell Biology, Blizard Institute, is looking for a Research Technician to perform further pre-clinical validation, utilising established 2D and 3D in vitro models, of compounds that can selectively kill senescent cells. The compounds have previously been identified using high-throughput screening approaches.

 

This technician post is open to motivated scientists interested in joining our active senotherapy research programme. Please contact Cleo Bishop (c.l.bishop@qmul.ac.uk) if you are interested in learning more about this post and the other senotherapy projects that this work will support.
 

More information HERE.

PhD Position on cardiac biomarkers in cellular senescence

Our lab has fully funded multidisciplinary PhD position (https://www.ulster.ac.uk/doctoralcollege/find-a-phd/795059) on cardiac biomarkers in cellular senescence. Student will learn cutting edge cell and molecular biology tools working in an intellectually stimulating environment at NICSM.

 

Please contact Dr Rai (t.rai@ulster.ac.uk) for informal enquiries. The deadline to apply for the project is 5th of February 2021, and interviews in March. Project starts September 2021.

 

L/Derry, Donegal is at the border of EU and UK, an area of an exceptional beauty with great amenities, relaxed way of life, mountains, hiking trails and sandy beaches in Northern Ireland and Republic of Ireland. C-TRIC based in the North West of Northern Ireland is a regional asset that makes it easy for Universities and Life and Health Science companies to work with the NHS to do research studies in order to improve patient care in our community. C-TRIC is a state-of-the-art research institute. C-TRIC is a not-for-profit company and personalised medicine institute based on the Altnagelvin Hospital site, the largest acute hospital outside Belfast. Created as a one of a kind tri-sector partnership between Derry City and Strabane District Council, Ulster University and the Western Health and Social Care Trust in late 2008, C-TRIC has expanded its portfolio of exciting research ever since, and continues to be supported by the HSC R&D Division of the Public Health Agency and several other grant funding bodies. 

Postdoc position available at Cambridge University, UK in Prof. Bennett's group

 

One postdoctoral position is now open at Cambridge in Prof. Bennett’s group for up to 4 years. The postdoc fellow will study senescence and cell proliferation in vascular disease and aging and develop novel transgenic systems for studying both the incidence and role of cell senescence.

Attached are the advertisements with detailed information.

Postdoc https://www.jobs.cam.ac.uk/job/28003/

2 Postdoctoral Positions in the Aird lab, Pittsburgh.
 

Two postdoctoral positions in the crosstalk between metabolism and the epigenome or metabolism and senescence in ovarian cancer are available in the laboratory of Dr. Katherine Aird at the University of Pittsburgh and UPMC Hillman Cancer Center (Pittsburgh, PA, USA). The research will focus on studying how metabolites affect senescence hallmarks such as the epigenome, DNA damage response, and/or microenvironment during ovarian tumorigenesis. This research will integrate cellular and molecular biology of in vitro and in vivo models of ovarian cancer, metabolomics, and high throughput genomics, and will be executed through multi-disciplinary and cross-institutional collaborations. More information can be found on our website airdlab.com.

The Aird Lab is seeking a Postdoctoral Associate who has recently earned, or nearing completion of, a PhD degree in cellular and molecular biology or a related field. Necessary research skills include standard molecular and cellular biology techniques. Prior experience in cancer research is not required. Experience with in vivo mouse models is preferred. In addition, candidates should have outstanding critical thinking and problem-solving skills and excellent written and oral skills. Salary is commensurate with experience and based on current NIH guidelines. Additionally, the candidate may be eligible for a Hillman Postdoctoral Fellowship for Innovative Cancer Research (https://hillmanresearch.upmc.edu/research/hillman-fellows/postdoctoral/).

The University of Pittsburgh School of Medicine is ranked #5 in NIH funding, and Pittsburgh has been consistently voted as one of the top livable cities in the US.

To apply for a position, qualified candidates should submit a one-page cover letter stating reasons for their scientific interest in the lab and career goals, a curriculum vitae including technical skills, and the names and contact information of three references. Submit your application to: Katherine Aird, PhD at kaa140 at pitt.edu. 

Postdoc position available at VIMM (Padova, ITALY) in Prof. Alimonti's group

 

 

A 1-year postdoctoral fellowship (renewable up to 3 years) is available in the lab of Prof. Andrea
Alimonti at VIMM (www.alimontilab.com; http://www.vimm.it/scientific-board/andrea-alimonti-2/)
to study senescence response and metabolism in prostate cancer and to develop novel effective
therapies for castration-resistant prostate cancer patients.

Below is the advertisment with the detailed information.

Postdoctoral Scientist
 

www.fondbiomed.it | www.vimm.it

Research Fellow in Bioinformatics – Senescence and Age-Related Pathologies Group

Institut Pasteur-Paris/France
 

A Postdoctoral Research Fellow position is available in the laboratory of Oliver BISCHOF, funded by the French National Institute of health INSERM, to study regulatory networks in senescence and aging. His research focuses on investigating senescent cells' role in aging and age-related diseases, with a particular focus on the integration of time-resolved multi-Omics data sets to dissect regulatory networks driving the senescence process. His team has shown by using integrative analysis and functional validation, important links between enhancer chromatin, transcription factor (TF) recruitment, and senescence competence (https://doi.org/10.1038/s41556-020-0529-5). A major goal is to unravel the senescence code and identify new therapeutic inroads to counteract senescent cells' detrimental impact on aging and age-related diseases. For more information visit https://research.pasteur.fr/en/team/group-oliver-bischof/.
 

Applications are invited from motivated, ambitious, and independent candidates who aim to investigate the role of cellular senescence in the context of aging using bioinformatics and systems biology approaches. Applicants must have a Ph.D. in a relevant field, have a proven track record, and are driven by scientific curiosity. An asset is an experience in chromatin
biology and expertise in the integrative bioinformatic analysis of OMICS data sets (e.g., ChIP-seq, ATAC-seq, and RNA-seq…). The position is initially for one year with a potential extension. Applications are evaluated on a rolling basis. To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of cellular senescence, please contact Dr. Oliver BISCHOF at oliver.bischof@pasteur.fr.

POSTDOC POSITION AVAILABLE IN LYON, FRANCE

We are looking for a highly motivated and dynamic postdoc. The postdoctoral researcher will be part of the Senescence, Cancer and Aging laboratory headed by David Bernard in Lyon, France (http://www.crcl.fr/240-Senescence,-cancer-and-aging.crcl.aspx?language=en-GB). The selected candidate will develop a project investigating the role of new mechanisms controlling cellular senescence, in particular secreted factors, and decipher their impacts in cancer and aging. Details of the project will be directly discussed with the candidates. The candidate will work under the supervision of David Bernard and Philippe Bertolino, in collaboration with other team members within the framework a French National Cancer Institute (INCA) supported project.

The applicant must hold a PhD in the field of molecular and cellular biology with good knowledge of cellular senescence, mouse models and/or cancer and aging biology. Experience in cell culture, manipulating gene expression as well as in classical cell and molecular biology techniques as well as some knowledge in using mice are required. Applicant should be a fist author of at least one publication related to the subject or skills required for the project. Candidates must have a positive attitude as a team member and should be able to communicate (oral and written skills) in English.

Our laboratory is part of the Cancer Initiation and Tumor cell Identity department inside the Cancer Research Centre of Lyon (CRCL - INSERM U1052 / CNRS 5286) located in Lyon, France. This center is affiliated to CNRS and INSERM French research agencies, and to Centre Léon Bérard Hospital. The successful applicant should start around december 2020. This contract is initially for 1 year, at least renewable twice. This is a full time job. Applicant should hold a PhD in the field of Biology, ideally since less than 1 year. Salary will be according to the CNRS scale. For application please send a detailed CV, a letter of motivation and contact for 3 referees to David Bernard (David.bernard@lyon.unicancer.fr) and Philippe Bertolino (philippe.bertolino@lyon.unicancer.fr).

POSTDOC POSITION AVAILABLE

 

Project: The interplay between cellular aging and immune response in human colorectal liver

metastasis: senescence as a new prognostic marker?

 

Humanitas Research Center, Milan, Italy

 

PI: Francesca Faggioli

 

Applications are invited for a Junior PostDoc position in a newly established laboratory in Humanitas Research Hospital and is available immediately. Our group studies the impact of cellular senescence in cancer and aging, with a special focus on metastasis.

 

Supported by a recently-awarded Italian Ministry of Health Grant, we have an opening for a motivated researcher at the postdoctoral level to study the impact of cellular senescence in colorectal hepatic metastasis. The position is for one year, renewable.

 

We are seeking for a talented and highly motivated candidate to study the crosstalk between metastasis and cellular senescence and how it could be modulated by immunity and metabolism.

 

The host Institution (Humanitas Research Hospital) offers an excellent working conditions including a set of eccellent core facilities and infrastructures. Humanitas is a world leading Institute on molecular mechanisms of innate immunity and inflammation.

 

Requirements:

- PhD degree in the field of basic or translational biology and experience in cancer immunology

- Minimum 3 years of relevant experience and familiar with cell culture and molecular biology techniques

- Be independent in learning necessary techniques, design and perform experiments

- Experience with human blood/tissue sample handling/processing (e.g. isolation of specific immune cell populations and their differentiation)

- Ability to design, perform complex experimental protocols and data analysis

- Expertise in mouse models is a plus

- Excellent in written and oral communication, preparation of data for lab meeting/publication/grants

- Team player with good interpersonal skills

- Committed and available to work flexible hours

- Creative and independent in problem solving

 

Salary will be proportionate to the candidate experience.

 

Candidates are invited to send their application (including a motivation letter, a CV, and two reference letters) to Francesca Faggioli (email: francesca.faggioli@humanitasresearch.it).

Research Fellow - Cell and Molecular Aging Laboratory - Mayo Clinic

 

https://jobs.mayoclinic.org/jobs/research-fellow-cell-and-molecular-aging-laboratory-137471br/

A Postdoctoral Research Fellow position is available in the laboratory of Joao Passos funded by the National Institute on Aging at NIH to study the role of mitochondrial apoptotic stress in senescence and aging. Dr. Passos directs the Cell and Molecular Aging Laboratory at Mayo Clinic. His research is focused on investigating the role of senescent cells in aging and age-related disease, with a particular focus on mitochondria and telomeres. His research has shown that mitochondria are key regulators of the pro-inflammatory phenotype characteristic of senescent cells. His team is currently investigating the mechanisms by which mitochondria drive senescence with the aim of finding new therapies to counteract the detrimental impact of senescent cells with aging and age-related diseases. For more information about the lab, please visit: https://www.mayo.edu/research/labs/cell-molecular-aging/overview

The postdoctoral researcher will work in the multidisciplinary and unique environment of Mayo Clinic, Rochester, where major discoveries in the field of cellular senescence and the development of senolytics have taken place. Applications are invited from motivated, ambitious and independent candidates who aim to investigate the role of cellular senescence and mitochondrial dysfunction in the context of aging. Applicants must have a PhD in a relevant field, be driven by scientific curiosity and have experience in cell and molecular biology. Experience in mitochondrial biology and mouse models is preferred. 
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of cellular senescence please contact Dr Joao Passos.

Senescence & HIV, Hospital Clinic, Barcelona

 

Post-doctoral fellowship position at the HIV Unit, Hospital Clinic, Barcelona, Spain.

A 2-year postdoctoral fellowship is available from October 2020 in the HIV Unit from Hospital Clinic (https://www.clinicbarcelona.org/ca/idibaps/arees-de-recerca/agressio-biologica-i-mecanismes-de-resposta/sida-i-infeccio-per-vih) under the direction of Dr Jose Alcami  (https://orcid.org/0000-0003-0023-7377).

 

The goal of the project is to characterise cellular senescence in HIV-infected patients using “in vitro” models and clinical samples. We are particularly interested in the identification of new biomarkers of senescence in peripheral blood lymphocytes and to typify the role of Natural Killer cells in this process.

 

We are looking for a young post-doc with experience in immunology and molecular biology able to exploit and interpret different techniques: immunohistochemistry, FACS analysis, RNAseq. The candidate should be able to work independently, interact with their colleagues and clinical staff of the institution and to collaborate in the different projects of the HIV Unit.

 

Salary will follow the postdoctoral fellow salary scale of IDIBAPS (net: 1800€/month).