Positions Related to Cell Senescence

POSTDOC POSITION AVAILABLE IN LYON, FRANCE

We are looking for a highly motivated and dynamic postdoc. The postdoctoral researcher will be part of the Senescence, Cancer and Aging laboratory headed by David Bernard in Lyon, France (http://www.crcl.fr/240-Senescence,-cancer-and-aging.crcl.aspx?language=en-GB). The selected candidate will develop a project investigating the role of new mechanisms controlling cellular senescence, in particular secreted factors, and decipher their impacts in cancer and aging. Details of the project will be directly discussed with the candidates. The candidate will work under the supervision of David Bernard and Philippe Bertolino, in collaboration with other team members within the framework a French National Cancer Institute (INCA) supported project.

The applicant must hold a PhD in the field of molecular and cellular biology with good knowledge of cellular senescence, mouse models and/or cancer and aging biology. Experience in cell culture, manipulating gene expression as well as in classical cell and molecular biology techniques as well as some knowledge in using mice are required. Applicant should be a fist author of at least one publication related to the subject or skills required for the project. Candidates must have a positive attitude as a team member and should be able to communicate (oral and written skills) in English.

Our laboratory is part of the Cancer Initiation and Tumor cell Identity department inside the Cancer Research Centre of Lyon (CRCL - INSERM U1052 / CNRS 5286) located in Lyon, France. This center is affiliated to CNRS and INSERM French research agencies, and to Centre Léon Bérard Hospital. The successful applicant should start around december 2020. This contract is initially for 1 year, at least renewable twice. This is a full time job. Applicant should hold a PhD in the field of Biology, ideally since less than 1 year. Salary will be according to the CNRS scale. For application please send a detailed CV, a letter of motivation and contact for 3 referees to David Bernard (David.bernard@lyon.unicancer.fr) and Philippe Bertolino (philippe.bertolino@lyon.unicancer.fr).

POSTDOC POSITION AVAILABLE

 

Project: The interplay between cellular aging and immune response in human colorectal liver

metastasis: senescence as a new prognostic marker?

 

Humanitas Research Center, Milan, Italy

 

PI: Francesca Faggioli

 

Applications are invited for a Junior PostDoc position in a newly established laboratory in Humanitas Research Hospital and is available immediately. Our group studies the impact of cellular senescence in cancer and aging, with a special focus on metastasis.

 

Supported by a recently-awarded Italian Ministry of Health Grant, we have an opening for a motivated researcher at the postdoctoral level to study the impact of cellular senescence in colorectal hepatic metastasis. The position is for one year, renewable.

 

We are seeking for a talented and highly motivated candidate to study the crosstalk between metastasis and cellular senescence and how it could be modulated by immunity and metabolism.

 

The host Institution (Humanitas Research Hospital) offers an excellent working conditions including a set of eccellent core facilities and infrastructures. Humanitas is a world leading Institute on molecular mechanisms of innate immunity and inflammation.

 

Requirements:

- PhD degree in the field of basic or translational biology and experience in cancer immunology

- Minimum 3 years of relevant experience and familiar with cell culture and molecular biology techniques

- Be independent in learning necessary techniques, design and perform experiments

- Experience with human blood/tissue sample handling/processing (e.g. isolation of specific immune cell populations and their differentiation)

- Ability to design, perform complex experimental protocols and data analysis

- Expertise in mouse models is a plus

- Excellent in written and oral communication, preparation of data for lab meeting/publication/grants

- Team player with good interpersonal skills

- Committed and available to work flexible hours

- Creative and independent in problem solving

 

Salary will be proportionate to the candidate experience.

 

Candidates are invited to send their application (including a motivation letter, a CV, and two reference letters) to Francesca Faggioli (email: francesca.faggioli@humanitasresearch.it).

Research Fellow - Cell and Molecular Aging Laboratory - Mayo Clinic

 

https://jobs.mayoclinic.org/jobs/research-fellow-cell-and-molecular-aging-laboratory-137471br/

A Postdoctoral Research Fellow position is available in the laboratory of Joao Passos funded by the National Institute on Aging at NIH to study the role of mitochondrial apoptotic stress in senescence and aging. Dr. Passos directs the Cell and Molecular Aging Laboratory at Mayo Clinic. His research is focused on investigating the role of senescent cells in aging and age-related disease, with a particular focus on mitochondria and telomeres. His research has shown that mitochondria are key regulators of the pro-inflammatory phenotype characteristic of senescent cells. His team is currently investigating the mechanisms by which mitochondria drive senescence with the aim of finding new therapies to counteract the detrimental impact of senescent cells with aging and age-related diseases. For more information about the lab, please visit: https://www.mayo.edu/research/labs/cell-molecular-aging/overview

The postdoctoral researcher will work in the multidisciplinary and unique environment of Mayo Clinic, Rochester, where major discoveries in the field of cellular senescence and the development of senolytics have taken place. Applications are invited from motivated, ambitious and independent candidates who aim to investigate the role of cellular senescence and mitochondrial dysfunction in the context of aging. Applicants must have a PhD in a relevant field, be driven by scientific curiosity and have experience in cell and molecular biology. Experience in mitochondrial biology and mouse models is preferred. 
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of cellular senescence please contact Dr Joao Passos.

Senescence & HIV, Hospital Clinic, Barcelona

 

Post-doctoral fellowship position at the HIV Unit, Hospital Clinic, Barcelona, Spain.

A 2-year postdoctoral fellowship is available from October 2020 in the HIV Unit from Hospital Clinic (https://www.clinicbarcelona.org/ca/idibaps/arees-de-recerca/agressio-biologica-i-mecanismes-de-resposta/sida-i-infeccio-per-vih) under the direction of Dr Jose Alcami  (https://orcid.org/0000-0003-0023-7377).

 

The goal of the project is to characterise cellular senescence in HIV-infected patients using “in vitro” models and clinical samples. We are particularly interested in the identification of new biomarkers of senescence in peripheral blood lymphocytes and to typify the role of Natural Killer cells in this process.

 

We are looking for a young post-doc with experience in immunology and molecular biology able to exploit and interpret different techniques: immunohistochemistry, FACS analysis, RNAseq. The candidate should be able to work independently, interact with their colleagues and clinical staff of the institution and to collaborate in the different projects of the HIV Unit.

 

Salary will follow the postdoctoral fellow salary scale of IDIBAPS (net: 1800€/month).

Three-year postdoctoral fellowship (1 position) in the Molecular Oncology group

directed by Prof. Andrea Alimonti at VIMM


A 3-year postdoctoral fellowship is available from April, 2020 in the lab of Prof. Andrea Alimonti at VIMM (www.alimontilab.com; http://www.vimm.it/scientific-board/andrea-alimonti-2/) to study senescence response and metabolism in prostate cancer and to develop novel effective therapies for castration-resistant prostate cancer patients. Alimonti lab works on the development of novel therapies that target the tumor immune response and cancer metabolism. In particular the lab focuses on the role-played by myeloid cells in prostate cancer and on lipid metabolism and treatment resistance (e.g. Di Mitri et al., Nature, 2014; Toso et al, Cell Rep, 2014; Kalathur et al., Nature Comm, 2015; Revandkar et al., Nature Comm, 2016; Calcinotto et al, Nature, 2018, Chen et al., Nature Genetics, 2018; Di Mitri et al., Cell Rep, 2019).

 

The successful candidate will be part of an ongoing effort to identify and target novel regulators of senescence and lipid metabolism, and to block myeloid cells recruitment and function in cancer. He/she will exploit different approaches (FACS analysis, RNAseq, proteomics, metabolomics, drug screenings) to identify gene pathways that sustain the survival of prostate cancer cells despite treatment. In parallel, he/she will generate novel mouse models to understand prostate tumor development and metabolism.
 

We are looking for a highly motivated individual with outstanding training in cancer metabolism or basic immunology to join an established, multicultural group of 7 talented scientists coming from different countries. Experience with in vivo cancer models would be considered a plus. We require at least one major first-author original research publication, the ability to drive discovery by working independently, interacting with colleagues with different backgrounds and establishing relevant collaborations.
 

We offer state-of-the-art labs and facilities, a stimulating environment, an exciting research project and multiple occasions of interaction with world leaders in the fields of cell biology, metabolism, cancer research and clinical translation. The PI fosters professional growth of postdoctoral associates: out of 4 past fellows, 3 secured independent PI positions in Europe and in Switzerland. Padua is a beautiful city with a thriving cultural scene, close to the seaside, Venice and the Dolomites. Salary will follow the University of Padua postdoctoral fellow salary scale (net: 1800€/month).
Interested candidates shall email Andrea Alimonti PA (nicoletta.delia@vimm.it, reference: AA PADOVA_PostDoc2020) a cover letter, a CV, and names and emails of two references. Shortlisted candidates will be invited for a two-day on-site interview.

2 POSITIONS AVAILABLE IN CAMBRIDGE, UK

Scientific Associate: http://www.jobs.cam.ac.uk/job/26965/

A position for a Scientific Associate is available within the Cellular Senescence and Tumour Suppressors Group of Masashi Narita at the CRUK Cambridge Institute. Our group has previously made significant advances in the mechanistic understanding of cellular senescence (Narita M et al, Science, 2011; Hoare M et al, Nature Cell Biology, 2016) (www.cruk.cam.ac.uk/research-groups/narita-group). This is an exciting opportunity to be the part of a successful and international group of scientists with world class expertise in tumour suppressor mechanisms, in an exciting cancer research institute.

Cellular senescence has been linked with both aging and tumorigenesis. An immune reaction against the senescent cell is known to be crucial in suppressing cancer development. Recently, our group has been investigating novel mechanisms of senescence-immune cell cross-talk in vivo, and is seeking a postdoctoral candidate to continue and develop this work.

This project will combine in vitro, ex vivo and in vivo approaches to understand the development of senescence within chronically inflammed, cancer-prone tissues. We are looking for a highly motivated individual to join our group. Applicants should have a PhD in a relevant scientific discipline. Previous experience in murine immunology, molecular biology, senescence, aging or another relevant discipline would be desirable, but not essential. Superb communication skills are a must.

Fixed-term: The funds for this post are available for 1 years in the first instance, potentially extendable dependent on funding.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Informal enquiries may be made to matthew.hoare@cruk.cam.ac.uk




Research Assistant: http://www.jobs.cam.ac.uk/job/27112/

A Research Assistant position is available within the Cellular Senescence and Tumour Suppressors Group of Masashi Narita at the CRUK Cambridge Institute. Our group has previously made significant advances in the mechanistic understanding of cellular senescence (www.cruk.cam.ac.uk/research-groups/narita-group). This is an exciting opportunity to be the part of a successful and international group of scientists with world class expertise in tumour suppressor mechanisms, in an exciting cancer research institute.

We are looking to hire an enthusiastic individual to support on-going projects within the lab that seek to understand the role of senescence and ageing in cancer development. The candidate will integrate into a team environment and assist on several on-going projects. This will involve a number of techniques including immunohistochemistry, image analysis, and flow cytometry. Training will be provided where necessary. Previous experience in immunology, molecular biology, or another relevant discipline would be desirable, but not essential.

The successful candidate should possess excellent communication skills, attention to detail, and be able to work effectively in a team environment. Funding is available for two years in the first instance, potentially extendable, depending on funding.

The role is available as either part-time or full-time, and we welcome applications from individuals who seek to work flexibly.

Please ensure that you upload a covering letter and CV in the Upload section of the online application, including names and contact details of two academic referees. The covering letter should outline how you match the criteria for the post and why you are applying for this role.

Informal enquiries may be made to liam.cassidy@cruk.cam.ac.uk

Research Fellow in Bioinformatics – Senescence and Age-Related Pathologies Group

Institut Pasteur-Paris/France
 

A Postdoctoral Research Fellow position is available in the laboratory of Oliver BISCHOF, funded by the French National Institute of health INSERM, to study regulatory networks in senescence and aging. His research focuses on investigating senescent cells' role in aging and age-related diseases, with a particular focus on the integration of time-resolved multi-Omics data sets to dissect regulatory networks driving the senescence process. His team has shown by using integrative analysis and functional validation, important links between enhancer chromatin, transcription factor (TF) recruitment, and senescence competence (https://doi.org/10.1038/s41556-020-0529-5). A major goal is to unravel the senescence code and identify new therapeutic inroads to counteract senescent cells' detrimental impact on aging and age-related diseases. For more information visit https://research.pasteur.fr/en/team/group-oliver-bischof/.
 

Applications are invited from motivated, ambitious, and independent candidates who aim to investigate the role of cellular senescence in the context of aging using bioinformatics and systems biology approaches. Applicants must have a Ph.D. in a relevant field, have a proven track record, and are driven by scientific curiosity. An asset is an experience in chromatin
biology and expertise in the integrative bioinformatic analysis of OMICS data sets (e.g., ChIP-seq, ATAC-seq, and RNA-seq…). The position is initially for one year with a potential extension. Applications are evaluated on a rolling basis. To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of cellular senescence, please contact Dr. Oliver BISCHOF at oliver.bischof@pasteur.fr.

Postdoctoral Position (RD22538). Senescence in Cancer

The laboratory of Dr Daniel Munoz-Espin offers a Postdoctoral Positions in the Department of Oncology at University of Cambridge. This post, funded by a CRUK Programme Foundation Award, are offered for 3 years in the first instance, with the possibility to be extended due to available funding. Details can be found in the following links:

- Postdoctoral Position (RD22538). Senescence in Cancer.  https://www.jobs.cam.ac.uk/job/25256/

 

Please contact Dr Daniel Munoz-Espin (dm742@cam.ac.uk) for any informal enquiries. The closing date of the advert is Sunday 8th November 2020.