Positions Related to Cell Senescence

Senescence & HIV, Hospital Clinic, Barcelona


Post-doctoral fellowship position at the HIV Unit, Hospital Clinic, Barcelona, Spain.

A 2-year postdoctoral fellowship is available from October 2020 in the HIV Unit from Hospital Clinic (https://www.clinicbarcelona.org/ca/idibaps/arees-de-recerca/agressio-biologica-i-mecanismes-de-resposta/sida-i-infeccio-per-vih) under the direction of Dr Jose Alcami  (https://orcid.org/0000-0003-0023-7377).


The goal of the project is to characterise cellular senescence in HIV-infected patients using “in vitro” models and clinical samples. We are particularly interested in the identification of new biomarkers of senescence in peripheral blood lymphocytes and to typify the role of Natural Killer cells in this process.


We are looking for a young post-doc with experience in immunology and molecular biology able to exploit and interpret different techniques: immunohistochemistry, FACS analysis, RNAseq. The candidate should be able to work independently, interact with their colleagues and clinical staff of the institution and to collaborate in the different projects of the HIV Unit.


Salary will follow the postdoctoral fellow salary scale of IDIBAPS (net: 1800€/month).

Post-doctoral researcher position available at Senolytic Therapeutics, Barcelona


Senolytic Therapeutics is a biotech startup company based in Barcelona focused on developing novel strategies to target and eliminate damaged cells to treat age-related diseases. We are currently recruiting a postdoctoral level researcher to oversee and carry out early discovery projects in the laboratory, as well as participate in project management when needed. Interested candidates must have a Ph.D. in biomedical sciences and should have experience working with a broad spectrum of techniques including cell culture, molecular biology and basic biochemical assays. Background in the field of aging, particularly in the context of senescence is preferred. Specific experience in CRISPR-based genetic screens and broad knowledge of all phases of drug discovery is a plus. Candidates should be highly ambitious and flexible, and have a natural curiosity about biology. Candidates should be able to multi-task, stay organized, and be capable of reaching concrete milestones on a defined timeline. Fluent written and spoken English is required.

Interested candidates should send their CV and further inquiries to Timothy Cash at tim.cash@senolytx.com.

Three-year postdoctoral fellowship (1 position) in the Molecular Oncology group

directed by Prof. Andrea Alimonti at VIMM

A 3-year postdoctoral fellowship is available from April, 2020 in the lab of Prof. Andrea Alimonti at VIMM (www.alimontilab.com; http://www.vimm.it/scientific-board/andrea-alimonti-2/) to study senescence response and metabolism in prostate cancer and to develop novel effective therapies for castration-resistant prostate cancer patients. Alimonti lab works on the development of novel therapies that target the tumor immune response and cancer metabolism. In particular the lab focuses on the role-played by myeloid cells in prostate cancer and on lipid metabolism and treatment resistance (e.g. Di Mitri et al., Nature, 2014; Toso et al, Cell Rep, 2014; Kalathur et al., Nature Comm, 2015; Revandkar et al., Nature Comm, 2016; Calcinotto et al, Nature, 2018, Chen et al., Nature Genetics, 2018; Di Mitri et al., Cell Rep, 2019).


The successful candidate will be part of an ongoing effort to identify and target novel regulators of senescence and lipid metabolism, and to block myeloid cells recruitment and function in cancer. He/she will exploit different approaches (FACS analysis, RNAseq, proteomics, metabolomics, drug screenings) to identify gene pathways that sustain the survival of prostate cancer cells despite treatment. In parallel, he/she will generate novel mouse models to understand prostate tumor development and metabolism.

We are looking for a highly motivated individual with outstanding training in cancer metabolism or basic immunology to join an established, multicultural group of 7 talented scientists coming from different countries. Experience with in vivo cancer models would be considered a plus. We require at least one major first-author original research publication, the ability to drive discovery by working independently, interacting with colleagues with different backgrounds and establishing relevant collaborations.

We offer state-of-the-art labs and facilities, a stimulating environment, an exciting research project and multiple occasions of interaction with world leaders in the fields of cell biology, metabolism, cancer research and clinical translation. The PI fosters professional growth of postdoctoral associates: out of 4 past fellows, 3 secured independent PI positions in Europe and in Switzerland. Padua is a beautiful city with a thriving cultural scene, close to the seaside, Venice and the Dolomites. Salary will follow the University of Padua postdoctoral fellow salary scale (net: 1800€/month).
Interested candidates shall email Andrea Alimonti PA (nicoletta.delia@vimm.it, reference: AA PADOVA_PostDoc2020) a cover letter, a CV, and names and emails of two references. Shortlisted candidates will be invited for a two-day on-site interview.