Positions Related to Cell Senescence

PhD Fellow in Dr Malu Martinez-Chantar Lab (Liver Disease Lab) at CIC bioGUNE, Vizcaya

Expires on December 10, 2021

Dr Malu Martinez-Chantar lab is looking for a highly motivated and outstanding student with experience in the senescence field to apply for la Caixa Retaining INPhNIT PhD Fellow in the Liver Disease lab.


Scientific-technical training capacity of the research team
Dr Malu Martinez-Chantar is part of Ciberehd ISCIII (Centro de Investigacion Médica en Red de Enfermedades Hepáticas y Digestivas), which the main objective is to promote excellence research into liver and digestive diseases in an international context.Thus, the student will have the possibility to enroll the exchange program belong to Ciber for Liver Disease for learning new techniques, clinical approaches and translational research. Also, the involvement of the PI in the select European group of Woman in Hepatology will increase the possibilities of collaboration with internationally recognized laboratories. Finally, the network of the PI not only in the area of hepatology but also in molecular and cellular biology has been intensified through an extensive participation in different national and international networks like Hepamet Registry, MetaboCancer Excellence Network and different European COST actions PROTEOSTASIS, TRANSAUTOPHAGY and MITOEAGLE. Importantly, the student will be also part of The Advanced Training Program to PhD in CIC bioGUNE.

Required documents and deadline
Applicants need a degree in biology, biochemistry, or a related field and a master degree that provides access to the PhD program. Candidates who have previous experience in senescence are welcome.
Students should send a letter of presentation and update CV to mlmartinez@cicbiogune.es

https://www.cicbiogune.es/people/mlmartinez
Application will be open in November 10, 2021

More info.

IRMB - Stem Cell and Genome Plasticity in Development and Aging, Team Leader Jean-Marc Lemaitre (INSERM U1183, Hôpital Saint-Eloi, Montpellier, France)

Open until fulfilment (last updated Nov 18, 2021)

We are seeking to appoint a postdoctoral researcher to better understand the role of cellular reprogramming associated to senescence escape to cancer initiation, to identify and validate novel targetable biomarkers of cancer stem cells. The postdoc will be based in the laboratory of Dr Jean-Marc Lemaitre, Group Leader of the Team Genome and Stem Cell Plasticity in Development and Aging, and co-Director of the Institute of Regenerative Medicine and Biotherapies of Montpellier, France. This position is funded for 3 years by INCa (French National Institute of Cancer), and is available from 1st January 2022.

Jean-Marc Lemaitre’s research aims to understand the epigenetic control of senescence/aging and age-related diseases. The team demonstrated that cellular aging is reversible by reprogramming through pluripotency and developed transient reprogramming strategies in in vivo and in vitro models, to escape from senescence. Candidates must have a PhD in the biological/biomedical sciences. A significant experience in cell senescence and stem cell reprogramming, as well as skills in bioinfomatics analysis are mandatory. A second Post-Doc, will be highly appreciated. A collaboration is engaged with Marco-Mendoza Parra (partner in the INCa project), leader of the Team SySfate from Genoscope (Evry, France), to further develop system biology analysis. These studies will enable us to dissect the role of senescence escape in cancer stem cells formation by a multidimentional profiling approach integrating, transcriptomes, epigenome, chromatin domain interactions in a time dependent manner. The ultimate objective is to identify new therapeutic targets to develop npharmacologically-active drugs for tumor eradication. The postdoc will carry out independent research and will be supported by an Engineer from the team.

How to apply: Applications are invited from outstanding and highly motivated candidates for a fixed term position as postdoctoral researcher in the group of Jean-Marc Lemaitre, at the Institute of Regenerative Medicine and Biotherapies in Montpellier.

Applications will include a cover letter, CV, and the contact details of three referees should be sent,
via e-mail to Jean-Marc Lemaitre : jean-marc.lemaitre@inserm.fr

More info.

Position For Postdoctoral Scientist To Work In Mammary Gland And Senescence, Gonzalez-Suarez Laboratory (CNIO, Spain)

Expires on December 14, 2021

The primary goal of Dr. Eva González-Suárez´s laboratory is to understand the signaling pathways implicated in epithelial stem cell fate, their alterations during cancer and metastasis, and the interactions between tumor cells and microenvironment. We have a multidisciplinary approach using mouse models, cell cultures, clinical samples and molecular and cell biology techniques to translate basic research into clinically relevant results.

We are looking for motivated postdoctoral scientists holding a PhD in a relevant discipline with interest in cancer biology. Candidates must have: - An outstanding publication record in peer review journals, with at least one publication in Q1. - Experience working with mouse models of cancer and patient derived xenografts. - Technical skills in tumor immunology, lineage tracing and molecular biology.

We are looking for motivated postdoctoral scientists holding a PhD in a relevant discipline with interest in cancer biology. Candidates must have: - An outstanding publication record in peer review journals, with at least one publication in Q1. - Experience working with mouse models of cancer and patient derived xenografts. - Technical skills in tumor immunology, lineage tracing and molecular biology.

Applications must include a CV with a cover letter and contacts for 2 references
Apply at https://www.cnio.es/en/about-the-cnio/employment-opportunities/ and send an email to: egonzalez@cnio.es. Please, clearly state in the subject of your email “ AIPOSTM6 Postdoc Position” and include a link to your most outstanding publication.

Starting date: December 2021

More info.

Postdoctoral Research Fellow Opening - Schafer Lab, Mayo Clinic (Minnesota, USA)

Open until fulfilment (last updated Nov 18, 2021)

The Schafer Lab at Mayo Clinic in Rochester Minnesota is seeking a Postdoctoral Fellow to participate in NIH-funded aging research. The candidate should have an interest in studying cellular senescence as a mechanism contributing to age-related systemic and brain dysfunction. Candidates with experience in advanced ‘omics’ or single cell phenotyping, including but not limited to single cell sequencing, mass cytometry, flow cytometry, or spatial profiling, are encouraged to apply. Experience with computational or bioinformatic analyses is highly desirable. Candidate should have a Ph.D., M.D., M.D./Ph.D., or equivalent doctoral degree with 0-3 years of post-Doctoral experience. Candidates should have a strong work ethic and good oral and written communication skills. Applicants should submit their CV, a cover letter containing a brief statement of how her/his expertise can contribute to the research described above and contact information for three references to: Schafer.Marissa@Mayo.edu


Additional information can be found here: https://jobs.mayoclinic.org/job/rochester/research-fellow/33647/18037092256

Postdoctoral Research Assistant at the Barts Cancer Institute, Centre for the Tumour Microenvironment (London, UK)

Expires on November 19, 2021

The role will involve leading a project that will focus on investigating the role of vascular endothelial-cell senescence in driving resistance to DNA-damaging therapies and metastasis formation in lung cancer.  The work will be based in the laboratory of Professor Kairbaan Hodivala-Dilke in a team of tumour microenvironment experts.

Essential requirements for this post include a PhD in a relevant biological subject and an undergraduate degree in a biological subject. Significant research laboratory experience in in vivo mouse cancer models, tissue culture, cell biology and deciphering molecular mechanism of action is essential.  Experience in the field of tumour blood vessel biology, senescence and DNA damage response, basic bioinformatics, and molecular biology and appropriate publication records would be an advantage.  A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential.

Informal enquiries should be addressed to Nick Summerfield at n.summerfield@qmul.ac.uk.

The closing date for applications is 19th November 2021.

Interviews are expected to be held in December 2021.

Apply here.

The Vall d´Hebron Institute of Oncology (VHIO) Seeks a “Research Physicist/Engineer to Join the Radiomics Group as PhD student in Magnetic Resonance Imaging” (Barcelona, Spain)

Expires November 11, 2021

The Radiomics Group at Vall d´Hebron Institute of Oncology´s (VHIO), headed by Raquel Perez-Lopez (MD, PhD), is currently seeking to recruit a Research Physicist/Engineer to undertake a 3-year doctoral (PhD) degree in Magnetic Resonance Imaging (MRI).

The successful candidate will be involved in the development of advanced MRI acquisition protocols and image analysis techniques, including artificial intelligence (AI), for oncological applications. He will be supervised by Dr Raquel Perez-Lopez (MD, PhD Radiology, primary supervisor) and Dr Francesco Grussu (PhD MRI Physics, secondary supervisor).

This post is a great opportunity to be involved in cutting-edge MRI acquisition and analysis within the translational research environment of the Vall d’Hebron Institute of Oncology (VHIO), Barcelona (Spain). VHIO is a leading Comprehensive Cancer Centre dedicated to translational cancer research and one of the world-leading drug-development centres for cancer care.

The Radiomics Group at VHIO is focused on medical image processing and the extraction of imaging biomarkers for precision medicine towards improving cancer patients’ care.

 

Examples of research projects in which the candidate will be involved are listed below.

 

1) Development of MRI biomarkers for non-invasive senescence detection. Senescence is a state of a cell’s life in which proliferation stops, and plays a key role in cancer drug development. The candidate will be involved in setting up advanced diffusion MRI acquisition and analysis protocols on a preclinical 9.4T scanner, with the aim of estimating cellular properties carrying a signature of senescence (e.g., cell size) non-invasively. The most promising preclinical protocols will be tested in clinical MRI settings at the Vall d’Hebron hospital.

 

2) Development of artificial intelligence (AI) algorithms for quality enhancement of clinical MRI. This project will be carried out on a rich data base of advanced and clinical 1.5T whole body diffusion MRI data, acquired on the same volunteers, which will be processed with AI methods such as convolutional neural networks (CNNs).

 

3) MRI-histology comparisons. The candidate will have access to co-localised histology (e.g., digitised multiplex immunohistochemistry images) and clinical/preclinical diffusion MRI data (e.g., time-dependent multi-shell scans), which will enable the validation of MRI biomarkers developed by the candidate against histological ground truth.

 

4) Design of MRI acquisition protocols based on computer simulations. The candidate will be involved in optimising the MRI acquisition protocols employed by the Radiomics group in clinical studies using numerical methods, such as Monte Carlo simulations. The Radiomics Group at VHIO is committed to the continue training of their scientists and a personal training and development plan will be agreed with the candidate. As the group expands, the candidate will progressively acquire a supervision role over pre-doctoral students and other junior investigators.

Potential candidates should submit a curriculum vitae and letter of intent via email addressed to Raquel Perez-Lopez: rperez@vhio.net

Expected employment starting date: 2022-01.

Apply here.

Postdoctoral position available in the “Senescence, Fibrosis and Cancer” team at the ONCOLille Institute, Lille (France)

Open until fulfilment (last updated Nov 1, 2021)

Applications are invited for a four-year postdoctoral position in the “Senescence, Fibrosis and Cancer” team headed by Corinne Abbadie in the CANTHER laboratory (https://canther.fr/en/canther-cancer-heterogeneity-plasticity-and-resistance-to-therapies/ ) at the ONCOLille Institute, Lille, France (https://www.oncolille.eu/ ). The recruited scientist will work on the SENSARCOME project, funded by INCa. The project will be conducted in collaboration with the Bernard Lopez team at the Institut Cochin, Paris (https://www.institutcochin.fr/la-recherche/drc/equipe-b-lopez ).

The objective of the SENSARCOME project is to investigate whether senescence induced by DNA single-strand breaks could be a step in the generation of secondary sarcomas after anti-cancer radiotherapy. The project will require the implementation of several technologies including culture of primary cells, molecular biology, cell imaging and in vivo experiments in mice.   

The applicants of any nationality must hold a PhD in an area related to the project and must have expertise in the required techniques. Candidates are encouraged to submit a full detailed CV, a cover letter describing their motivation, and reference letters to corinne.abbadie@ibl.cnrs.fr

Expected employment starting date: 2022-01.

Apply here.

Postdoctoral Fellow on Senescence in Muscle Regeneration/Degeneration in Aging (Paris, France)

Expires on November 15, 2021

The Cellular Plasticity and Disease Modelling laboratory is looking for a highly motivated and creative postdoctoral fellow to work with us on senescence in muscle regeneration/degeneration during aging.


Research topic: Cellular senescence is a stress response characterized by a stable cell-cycle arrest and a robust senescence-associated secretory phenotype (SASP). Our laboratory aims to elucidate senescence heterogeneity in specific physiological and pathological conditions, with a particular interest in its opposite impact on tissue regeneration during aging. We combine mouse genetics, cellular and molecular biology tools with single cell RNAseq and proteomic approaches to understand senescence pleiotropic roles and provide necessary precision in developing interventions targeting the detrimental effects of senescence in diseases. Meanwhile, we are also actively exploring the interplay between somatic reprogramming and senescence in the context of rejuvenation and aging.

The main objective of this project is to characterize the temporal regulation of senescence heterogeneity in the context of muscle regeneration and pathology, to exploit means to specific targeting the detrimental effects of senescence in muscle degeneration.


We are located at the Development and Stem Cell Biology Department at Institut Pasteur in Paris, which offers state-of-art core facilities in an excellent international and multidisciplinary scientific environment.

More info here.

Senescent Cells in Aging and Age-related Diseases
Available postdoctoral position at Mayo Clinic – laboratory of Darren Baker, Ph.D.

Expires on November 30, 2021


Applications are invited to consider a postdoctoral research fellow position in the laboratory headed by Darren J. Baker at the Mayo Clinic in Rochester, Minnesota (http://www.mayo.edu/research/faculty/baker-darren-j-m-s-ph-d/bio-00027985). Specific interests of the laboratory encompass defining the alterations underlying senescence entry and the mechanistic contribution of senescent cells to various age-associated diseases. In addition to being involved with other ongoing projects, the recruited scientist will work specifically on studies utilizing neurodegenerative disease mouse models and senescent cell targeting strategies. The project will require the implementation of several technologies, from in vitro studies with primary cells to in vivo experiments in mice.
 
The selected candidate should have a Ph.D., M.D., or equivalent doctoral degree with 0-2 years of post-doctoral experience. Strong oral and written communication skills are a requirement. Expertise in working with animal models and extensive neuroscience knowledge is desirable, however we are seeking members to integrate seamlessly into the laboratory. This involves a strong work ethic and aspiration to understand the mechanisms driving senescence-associated pathologies. Candidates may need to complete an on-site interview process to present their work to date and meet with current lab members. 
 
Applicants should submit his/her CV including a list of publications, a cover letter containing a brief statement of how his/her expertise can contribute to the research described above and their motivation, and the name and contact information of three references to: Darren Baker, Ph.D., at baker.darren@mayo.edu

More info here.

Postdoctoral position on Senescence in Cancer in Cambridge (UK)

Expires on December 5, 2021

We are seeking to appoint a postdoctoral researcher to better understand the role of cellular senescence in cancer and to identify and validate novel targetable biomarkers. The postdoc will be based in the laboratory of Dr Daniel Munoz-Espin, Group Leader in the Department of Oncology at University of Cambridge and co-Director of the Thoracic Cancer Programme. This post funded by a Cancer Research UK (CRUK) Programme Foundation Award is available from 1st January 2022.

Dr Munoz-Espin's research programme aims to understand the mechanisms and processes that contribute to cancer initiation, progression and relapse, which remains a formidable challenge in oncology, and how to use this knowledge for the development of more efficient therapeutic strategies in precision medicine. We are looking for ambitious and highly motivated researchers to explore the impact of senescence in cancer, and to identify and validate novel targetable biomarkers of cellular senescence in 2D/3D cultures and in vivo, with a particular focus on lung tumours.

 

The laboratory of Dr Munoz-Espin (https://www.munoz-espinlab.com) is part of the Early Detection Programme of the CRUK Cambridge Centre, (http://www.earlydetectioncambridge.org.uk/). Our location at Cambridge Biomedical Campus affords our members ready access to state-of-the-art research equipment, clinical facilities, and the opportunity to forge collaborations with world-class laboratory scientists and clinicians.

Informal enquiries are welcomed and should be directed to Dr Munoz-Espin at dm742@cam.ac.uk.

 

Fixed-term: The funds for this post are available for 3 years in the first instance, with the possibility of extension up to 5 years.


Apply here: https://www.jobs.cam.ac.uk/job/29923/
 
https://www.nature.com/naturecareers/job/research-associate-senescence-in-cancer-fixed-term-university-of-cambridge-745288