2 researcher positions are offered to lead a group aiming at the study of (1) Reservoirs and Cure Strategies in HIV infection and (2) Cellular Senescence and Strategies anti-aging in HIV infection.

 

The HIV Unit of the Hospital Clinic de Barcelona is made up of more than 50 professionals and folows 7,000 people living with HIV. The HIV Unit develops clinical research projects together with basic research projects, that include the study of viral reservoirs in different clinical scenarios.
 

The Unit has its own laboratory with one senior researcher, two junior post-doctoral researchers, two pre-doctoral researchers and four technicians. It has BSL2, BSL3 facilities and equipment for the study of reservoirs including Digital Droplet PCR. The research institute (IDIBAPS) has platforms for Cytometry, sequencing and, in the near future, single cell analysis.
 

The aim of this call is to enhance this activity through the recruitment of a researcher who will deepen and develop original lines of basic research work in the field of reservoirs and functional cure of HIV, and collaborate with the lines currently developed by the group.

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More details about position (1) HERE, and position (2) HERE. 

Are you passionate about unraveling the mysteries of brain aging and eager to make a meaningful impact on age-related cognitive decline? The Schafer Lab is seeking a Postdoctoral Fellow to contribute to our cutting-edge NIH-funded research in the areas of aged brain cell senescence and molecular spatial mapping. Candidates should have experience in

neuroscience research and an interest in exploring age-dependent changes in brain microenvironments through high- dimensional spatial omic platforms. Join us on a journey of discovery, innovation, and collaboration, in which we are dedicated to identifying and targeting cell fates and mechanisms to counter late-life cognitive decline.
 

Desired Qualifications and Experience:
- Interest in brain aging
- Background in neuroscience
- Highly desirable expertise in any of the following domains:
   o Transgenic mouse model experimentation
   o Imaging and microscopy
   o Single cell sequencing or molecular spatial mapping
   o Cytometry
   o Advanced bioinformatics analyses
- Strong work ethic and communication skills
 

Candidates are invited to submit the following materials to Schafer.Marissa@Mayo.edu or by searching for “Schafer” at
https://jobs.mayoclinic.org/ :
- CV: Provide your detailed curriculum vitae showcasing your educational background, research experience, and accomplishments.
- Cover Letter: Include a brief statement explaining how your expertise aligns with our research.
- References: Share the contact information for three professional references who can vouch for your qualifications and dedication.
 

This is your chance to be a part of a highly collaborative, dynamic, and pioneering team dedicated to making a real difference in the field of brain aging. Don't miss out on the opportunity to shape the future of brain health research – apply today and become an integral part of the Schafer Lab's exciting discoveries!

Prof David Ferenbach is looking for a Postdoctoral Research Fellow in renal senescence and fibrosis signalling based in the Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh.

This post is advertised as full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. 

 

The Opportunity:

This fellowship forms part of an MRC-funded Senior Clinical Fellowship, based in the Institute for Regeneration and Repair – home to over 1000 research staff and students.  Its focus is on the identification of novel pathways linking senescent epithelia to tissue fibrosis in human chronic kidney disease. The post holder will lead the validation of these pathways using advanced cell culture approaches to interrogate the interactions between healthy and senescent renal epithelia and renal leukocytes and fibroblasts. Further work will explore the potential for these pathways to be targeted in vivo to promote senescent cell clearance and prevent senescent cell accumulation with ageing and tissue injury. 

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Your skills and attributes for success: 

• PhD or equivalent (or will be shortly awarded a PhD) in biological sciences.   

• Experience of in vivo work 

• Experience of in vitro work, ideally working with models of epithelial cell culture ± co-culture 

• Experience of a several biological assays for determining mechanisms, e.g., several of: histology, light or fluorescent microscopy, absorbance assays, ELISA, flow cytometry, DNA/RNA extraction, qPCR. 

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Click to view a copy of the full job description

Staffan Strömblad’s research group focuses on the role of cell-matrix interactions in cancer. The group holds a mix of senior researchers, postdocs and students and uses in its research a broad array of methods, including advanced light microscopy and image analysis, transgenic mouse cancer models, multiplexed tissue image analysis, modern global omics techniques and a range of molecular, biochemistry and cell-based methods.

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You will initially join a senior postdoc in an ongoing project on the role of cellular senescence in cancer development and then use this as the base to branch out your own research direction. You will perform experiments in 2D and 3D cell models, transgenic mouse cancer models, and in tissues from patients, and perform various analyses such as multiplexed image-based analysis of tissues, scRNA-seq and spatial transcriptomics, confocal microscopy imaging and analysis, and various cell and biochemical assays. You will take a strong responsibility for developing the project, design experiments, and analyze, compile, and present your data.

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Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
 

Apply HERE.

Links for further information:

https://ki.se/en/bionut/cell-biology-of-cancer-staffan-stromblad-0

https://ki.se/en/research/brect-breast-cancer-theme-center

https://ki.se/en/bionut/department-of-biosciences-and-nutrition

https://ki.se/en/bionut/live-cell-imaging-core-facility-lci

We are currently seeking a Postdoctoral Researcher to join the research group of Federico Pietrocola. The focus of this position is to investigate the connection between aging and cancer, with a specific emphasis on understanding the impact of cellular senescence on the biology of lung cancer. The primary objective of the project is to explore how senescent cells in the microenvironment influence the host immune response, tumor progression, and the response to anti-cancer immunotherapy.

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To successfully accomplish these goals, the candidate will have access to cutting-edge murine models of disease and local facilities equipped for high-throughput genomics, flow cytometry, and imaging analysis. Furthermore, the candidate will have the opportunity to collaborate with internationally renowned scientists specializing in the fields of cellular senescence and tumor immunology.

 

We are seeking a talented and highly motivated scientist who possesses a doctoral degree and a strong background in Cancer Biology. Previous experience working with animal models, particularly mouse models, and murine tumor models is a mandatory requirement. Prior knowledge in immunology and tumor immunology will be highly regarded during the selection process. Evaluation criteria will also include personal skills such as motivation, independence, and the ability to work effectively within a team.

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More info HERE.

JOB INFO

• Job Identification: 8876

• Job Category: Academic

• Posting Date: 06/11/2023, 14:41

• Apply Before: 27/11/2023, 23:59

• Job Schedule: Full time

• Locations: Edinburgh - BioQuarter (Royal Infirmary), Edinburgh - BioQuarter, EH16 4UX, GB (N/A - Do not use)

• Health and Safety Requirements: Key hazards identified (plan is in place)

• Criminal Record Check: No criminal record check required

• Contract Type: Fixed Term

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JOB DESCRIPTION

UE07: £37,099 - £44,263 per annum

Clinical Sciences / Institute for Regeneration and Repair / Centre for Inflammation Research           

Full-time: 35 hours per week

Contract Type - Fixed Term dates: 3 years, 10 months

We are looking for a Bioinformatician to study cellular responses to injury and aging at using single cell and spatial technologies.  The post will be based in the Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh with Professor David Ferenbach.

This post is advertised as full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns.  We are also open to considering requests for hybrid working (on a non-contractual basis) that combines a mix of remote and regular on-campus working.  

 

The Opportunity:

This fellowship forms part of a MRC-funded Senior Clinical Fellowship, based in the Institute for Regeneration and Repair – home to over 1000 research staff and students. Its focus is on the identification of novel pathways linking senescent epithelia to tissue fibrosis in human chronic kidney disease. The post holder will lead the computational identification and analysis of these pathways using spatial transcriptomic analysis of human kidney biopsies, and single cell resolution analysis of renal cell populations obtained ex vivo / in vitro.  Further work will explore the potential for these pathways to be targeted in vivo to promote senescent cell clearance and prevent senescent cell accumulation with ageing and tissue injury. 

 

Your skills and attributes for success: 

• A PhD, or near completion, in Mathematics, Physics, Computational Science, Genomics, Genetics, Computational Biology (or similar) and a passion for problem solving.

• Understanding of single cell transcriptome and/or genome data analysis.

• Proficiency in analysing NGS sequencing data and (RNA-seq, ATAC-seq, Chip-seq, single cell) 

• An understanding, experience and published outcomes from analysing and interpreting large datasets using at least one statistical package (e.g. R/SPLUS, SAS) and proficiency with scripting languages (R/Python) and Linux/Bash

• Experience in the analysis of high throughput biological datasets.

 

Click to view a copy of the full job description (opens new browser tab) 

As a valued member of our team, you can expect: 

An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family friendly initiatives, flexible working and much more. Access our staff benefits page for further information and use our reward calculator to find out the total value of pay and benefits provided. 

ABOUT THE TEAM

(Director, Professor David Dockrell) aims to apply peer-reviewed interdisciplinary research programmes and focussed collaboration, to characterise and manipulate key control points in inflammation across the spectrum of acute and chronic inflammation.  The CIR aims to characterise what promotes health and resilience in order to prevent the harmful consequences of inflammation in clinical medicine. Effort is targeted at: inhibiting the initiation of inflammation by blocking specific molecular triggers and by modulating cellular and tissue responses resulting in organ dysfunction; finding new approaches to modulate established inflammatory responses to limit tissue injury; and promoting safe resolution of inflammation to restore healthy structure and function of tissue. A particular current focus is on tissue fibrosis - the result of longstanding inflammation, with programmes looking at the mechanisms underpinning resolution of fibrosis and its non-invasive monitoring and imaging. The CIR has a broad interest in inflammatory disease in a range of tissues including in the lungs, kidney, liver, pancreas, bowel, bone, joints, skin, heart and brain. Importantly, the principles derived will have ready application to inflammatory and reparatory responses in virtually all physiological and pathological settings, including cancer and infection (not least COVID-19).  The CIR is located in state of the art facilities at the Queen's Medical Research Institute adjacent to the clinical facilities on the BioQuarter Campus, Edinburgh.

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APPLY

Juan-Pedro Martinez-Barbera is looking for a researcher with experience in a relevant area of biosciences or medical sciences (for example cancer, cell senescence, mouse modelling) to work on a research programme focused on the role of cellular senescence in paediatric High-Grade Glioma (pHGG). These are clinically aggressive, malignant tumours with an abysmal prognosis. The focus will be on histone-mutated diffuse high-grade glioma, but the successful candidate will be encouraged to develop parallel research projects on other paediatric or adult brain cancers.

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This is a unique opportunity for an experienced postdoc to have an active role in leading a research programme with a focus on senescence and cancer. The post is supported for 5 years from a Research Programme funded by the Brain Tumour Charity.

 

Senescent cells have been shown to contribute to tumour promotion through their paracrine signals in adult and paediatric tumours, including brain tumours (e.g. PIMD: 29670296; PIMD: 35241831). Building on our current findings (e.g. PMID: 37267953; PMID: 37414988; unpublished results), the appointed candidate will explore the interactions between senescent cells within the tumour and tumour microenvironment in vitro and in vivo in mouse and human models.

 

The appointee will dissect the role of senescent cells using combined approaches, including cell culture, organoid culture, mouse modelling and molecular data (e.g. single cell RNA-seq and spatial transcriptomics). Building on our current findings (e.g. PMID: 37267953; PMID: 37414988; unpublished results), the appointed candidate will explore the interactions between senescent cells within tumour and tumour microenvironment in vitro and in vivo in mouse and human models. The appointee will dissect the role of senescent cells using combined approaches, including mouse modelling (e.g. genetic models, in utero electroporation, orthotopic transplantation of tumour cells, etc) and molecular data (e.g. single cell RNA-seq and spatial transcriptomics). The host lab has proven experience in the generation of preclinical models and the study of cellular senescence in vivo (e.g. PIMD: 29670296; PMID: 24094324;PMID: 21636786;PMID: 31699993;PMID: 29180744; PMID: 29541918; PMID: 33378554). More information on the lab research can be found at: https://rps.ucl.ac.uk/userprofile.html?uid=3970&em=false The salary offered is £40,524 - £47,478 per annum and is funded for 5 years in the first instance.

 

More details here.

A 4-year PhD Studentship in senescence in paediatric high-grade glioma funded by the Brain Tumour Charity is available within the UCL GOS Institute of Child Health (London, UK). The studentship is expected to start in February/March 2024, under the supervision of Juan Pedro Martinez-Barbera and Jesus Gil. 

 

Project title:

Identification and preclinical evaluation of novel senolytics and senescence inducers against H3-mutated paediatric diffuse midline glioma.

 

Background:

Diffuse midline glioma (DMG) are devastating tumours with an abysmal prognosis. The median survival is less than a year after diagnosis. Our preliminary data support a key role of senescent cells in the development of DMG and in relapse after therapy. This project aims to identify ways to exploit senescence as a new therapeutic target against these devastating paediatric brain tumours.

 

Hypothesis/Aims:

1. Perform functional screens to identify vulnerabilities in senescent DMG cell lines.

2. Identify matched pairs of senescent inducers/senolytics against DMG.

3. Evaluate preclinically the efficacy of these new compounds and combination therapies.

 

Research and Policy outputs:

Technically, the PhD student will learn and become an expert in high content image screening methods, including the use of artificial intelligence to assess senescence in vitro. A variety of molecular techniques including qRT-PCR, RNA-seq, WB, drug/dose response analyses and immunocytochemistry will be used throughout the PhD. Mouse work may also take place at the late stages of the project to validate new drugs in vivo. Additionally, the PhD student will acquire a solid knowledge in the field of senescence in cancer. This is expected to result in several publications.

senolytics against these tumours.

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More information

The Dörr lab (https://www.mdc-berlin.de/doerr) at the Experimental and Clinical Research Center (ECRC) of the Charité-Universitätsmedizin and the Max Delbrück Center (MDC) for Molecular Medicine in Berlin is currently looking for motivated postdoctoral research associates with experience in cancer biology, who want to dissect fundamental questions in tumor heterogeneity and therapy resistance of neuroblastomas in vitro and in vivo. The successful candidate will develop research projects in close cooperation with other research groups of the collaborative research center CRC1588:Decoding and Targeting Mechanisms of Neuroblastoma Evolution (https://www.bsio-cancerschool.de/crc1588), which is funded by the German Research Foundation. Candidates with strong experience in tumor mouse models, functional proteomics, and signal transduction are especially encouraged to apply. She/He will define the impact of genetic and phenotypic tumor heterogeneity on therapy resistance in neuroblastoma cell lines, neuroblastoma mouse models, patient-derived xenografts (PDX) and patient samples before and after treatment with cytotoxic or targeted therapies with the goal to identify and test new therapeutic vulnerabilities. 

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We are an interdisciplinary and international team of young, enthusiastic scientists and doctors. We study mechanisms of tumor heterogeneity and treatment resistance on both the genetic and phenotypic level. We have generous access to state-of-the-art equipment by the facilities of the Charité and the MDC with multiple opportunities for translational pediatric cancer research. Project collaborations with different laboratories in Germany, particularly within the CRC, and abroad, such as the Hondele lab (Biozentrum Basel, Switzerland) will be available. Detailed project descriptions can be found in the job postings on our website: https://www.mdc-berlin.de/doerr#t-jobs

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