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Post-Doc in the Dörr Lab in Berlin

The Dörr lab (https://www.mdc-berlin.de/doerr) at the Experimental and Clinical Research Center (ECRC) of the Charité-Universitätsmedizin and the Max Delbrück Center (MDC) for Molecular Medicine in Berlin is currently looking for motivated postdoctoral research associates with experience in cancer biology, who want to dissect fundamental questions in tumor heterogeneity and therapy resistance of neuroblastomas in vitro and in vivo. The successful candidate will develop research projects in close cooperation with other research groups of the collaborative research center CRC1588:Decoding and Targeting Mechanisms of Neuroblastoma Evolution (https://www.bsio-cancerschool.de/crc1588), which is funded by the German Research Foundation. Candidates with strong experience in tumor mouse models, functional proteomics, and signal transduction are especially encouraged to apply. She/He will define the impact of genetic and phenotypic tumor heterogeneity on therapy resistance in neuroblastoma cell lines, neuroblastoma mouse models, patient-derived xenografts (PDX) and patient samples before and after treatment with cytotoxic or targeted therapies with the goal to identify and test new therapeutic vulnerabilities. 

We are an interdisciplinary and international team of young, enthusiastic scientists and doctors. We study mechanisms of tumor heterogeneity and treatment resistance on both the genetic and phenotypic level. We have generous access to state-of-the-art equipment by the facilities of the Charité and the MDC with multiple opportunities for translational pediatric cancer research. Project collaborations with different laboratories in Germany, particularly within the CRC, and abroad, such as the Hondele lab (Biozentrum Basel, Switzerland) will be available. Detailed project descriptions can be found in the job postings on our website: https://www.mdc-berlin.de/doerr#t-jobs

More details here.

PhD student studying pathological senescence

We are looking for an enthusiastic and ambitious PhD candidate in the Laboratory of Cellular senescence and age-related pathologies, headed by Prof. Marco Demaria to work on a project studying the contribution of senescent cells to inflammatory and fibrotic chronic disease.

Job description
Cellular senescence is a complex tumor-suppressive mechanism induced by many different stresses. Senescent cells are characterized by growth arrest, changes in morphology and gene expression, and the secretion of inflammatory cytokines, proteases and other molecules that can alter the tissue microenvironment (a phenomenon termed the senescence-associated secretory phenotype or SASP). For an unknown mechanism, senescent cells increase with age, and are evident at sites of numerous age-related pathologies and pre-cancerous lesions. Recent results show that life-long elimination of senescent cells can prevent the development of certain age-related pathologies in a mouse model of segmental accelerated aging, strongly supporting the idea that senescent cells can be deleterious.

 

The Demaria lab is interested to dissect the molecular phenotypes of cellular senescence induced by different stimuli, and to characterize how they can promote age-related dysfunctions.

 

The proposed project aims to determine the mechanisms by which senescent cells contribute to human fibrotic and inflammatory diseases. A major focus will be on characterizing cell senescence at single-cell resolution in pulmonary dysfunctions and autoimmune diseases, and to validate potential targets using pre-clinical systems. The project will use human biopsies, mouse models and cellular systems, some already available and some under current development. Moreover, it will include the use of publicly available datasets of human tissues. The project is part of a collaboration that includes physicians and a large pharma company.

More info HERE.

Postdoc position in Cellular senescence and age-related pathologies

ERIBA are looking for an enthusiastic and ambitious post-doc candidate in the Laboratory of Cellular senescence and age-related pathologies, headed by Prof. Marco Demaria, to study a novel intervention against cellular senescence and the consequence for extending healthy longevity.

The proposed project aims to validate the newly discovered mechanisms for senescent cells survival in both cell culture and in tissues. In parallel, we will screen a curated library of small molecules to identify compounds that achieve selective senescent cells elimination and improves frailty and another age-related dysfunctions in mouse models. In addition, we will analyse datasets derived from human cohorts, and search for correlation between health/disease and the newly discovered mechanisms.

For more info, visit Postdoc position in Cellular senescence and age-related pathologies (werkenbijumcg.nl)

Postdoctoral position at  Rutgers Robert Wood Johnson Medical School Department of Pharmacology, NJ, USA

The Martínez Zamudio Lab (https://sites.rutgers.edu/martinez-zamudio-lab/) is looking for a motivated fresh PhD/early stage postdoctoral scientist with experience in epigenetics to join the laboratory at Rutgers Robert Wood Johnson Medical School Department of Pharmacology.

The candidate will spearhead the experimental and computational arms of ongoing research projects focusing on the function of transcription factor (TF) networks in mediating cell fate transitions at the early stages of oncogenic transformation (focusing on colorectal and/or breast cancer) as well as during aging of the immune system (focusing on monocytes and CD8+ T cells).

 

Details on the application process can be found here: https://jobs.rutgers.edu/postings/186475.

 

If interested, please reach out to me at ricardo.martinezzamudio@rutgers.edu.

2 positions available at the Blizard Institute in London, UK

John Connelly and Cleo Bishop are looking for two new people (1 post doc and 1 technician) to join us in exploring the biophysical regulation of nucleolar structure and function in senescent cells. This multi-disciplinary collaborative project is fully funded for three years. If you’d like to find out more, please get in touch with John or Cleo directly for an informal discussion about the roles. The full job descriptions can be found here: postdoc and technician, and close on the 8th March 2023.

 

The Blizard Institute was established in 2003 and is one of six Institutes within the Faculty of Medicine and Dentistry, QMUL. The Institute comprises approximately 350 staff based in four academic Centres and one Public Engagement Centre, and supports a combined total of c750 postgraduate research and taught students. The Institute aims to deliver excellence in all aspects of research, teaching and clinical service.

Post-Doc at UCL GOS Institute of Child Health (London)

Juan-Pedro Martinez-Barbera is looking for a researcher with experience in a relevant area of biosciences or medical sciences (for example cancer, cell senescence, mouse modelling) to work on a research programme focused on the role of cellular senescence in paediatric High-Grade Glioma (pHGG). These are clinically aggressive, malignant tumours with an abysmal prognosis. The focus will be on histone-mutated diffuse high-grade glioma, but the successful candidate will be encouraged to develop parallel research projects on other paediatric or adult brain cancers.

 

This is a unique opportunity for an experienced postdoc to have an active role in leading a research programme with a focus on senescence and cancer. The post is supported for 5 years from a Research Programme funded by the Brain Tumour Charity.

 

Senescent cells have been shown to contribute to tumour promotion through their paracrine signals in adult and paediatric tumours, including brain tumours (e.g. PIMD: 29670296; PIMD: 35241831). Building on our current findings (e.g. PMID: 37267953; PMID: 37414988; unpublished results), the appointed candidate will explore the interactions between senescent cells within the tumour and tumour microenvironment in vitro and in vivo in mouse and human models. The appointee will dissect the role of senescent cells using combined approaches, including cell culture, organoid culture, mouse modelling and molecular data (e.g. single cell RNA-seq and spatial transcriptomics). The salary offered is £40,524 - £47,478 per annum and is funded for 5 years in the first instance.

 

More details here.

Postdoctoral studies in Senescence and Cancer (Scholarship)

We are currently seeking a Postdoctoral Researcher to join the research group of Federico Pietrocola. The focus of this position is to investigate the connection between aging and cancer, with a specific emphasis on understanding the impact of cellular senescence on the biology of lung cancer. The primary objective of the project is to explore how senescent cells in the microenvironment influence the host immune response, tumor progression, and the response to anti-cancer immunotherapy.

To successfully accomplish these goals, the candidate will have access to cutting-edge murine models of disease and local facilities equipped for high-throughput genomics, flow cytometry, and imaging analysis. Furthermore, the candidate will have the opportunity to collaborate with internationally renowned scientists specializing in the fields of cellular senescence and tumor immunology.

 

We are seeking a talented and highly motivated scientist who possesses a doctoral degree and a strong background in Cancer Biology. Previous experience working with animal models, particularly mouse models, and murine tumor models is a mandatory requirement. Prior knowledge in immunology and tumor immunology will be highly regarded during the selection process. Evaluation criteria will also include personal skills such as motivation, independence, and the ability to work effectively within a team.

More info HERE.

3 Group Leaders Recruitment @MIA-Portugal - Multidisciplinary Institute of Ageing

The Multidisciplinary Institute of Ageing of the University of Coimbra-Portugal (MIA-Portugal) is recruiting new group leaders to strengthen its research on the biology of Ageing. 
 
Considering your expertise and contribution to the Ageing field, we would be truly grateful to you if you could disseminate these job opportunities throughout your network of contacts (Flyer in annex).
 
There are more job opportunities available: https://www.uc.pt/mia/the-institute/careers/

Postdoctoral position at St George’s, University of London, UK

This 9-month postdoctoral scientist position is to work with Dot Bennett and Anissa Chikh, collaborating with Cleo Bishop (QMUL), in a novel pilot project to find the mechanism(s) of activation of the core senescence mediator and melanoma suppressor p16 (CDKN2A) in normal human cells, by cell-senescence triggers like DNA damage.  High-quality data from the project will be key in application for longer-term support.  Funded by the Melanoma Foundation.  

 

Details and job descriptions are here: Postdoctoral Research Scientist - Jobs at St. George's.  
 

Closes 14 March.

Research Fellow at UCL (United Kingdom)

UCL are looking for a researcher with experience in mouse genetics, embryology and tumorigenesis to work on a research programme focussed on the role of senescence in paediatric low-grade glioma. The post will be based within the new Birth Defects Research Centre, at the UCL Institute of Child Health.

 

The post will be focused on the study of senescence in paediatric low-grade glioma, but the successful candidates is expected to develop collaborative work on ongoing lab projects studying the role of cell senescence in other paediatric brain tumours.

 

The project has three main objectives: (1) to continue previous work on this subject aiming to finalise a manuscript that is currently in preparation; (2) to develop and analyse new preclinical models of pLGG; (3) to perform drug screens to identify senescence inducers and senolytics against these tumours.

 

More information on the lab research

 

To apply, go to Job details: Research Fellow B02-03991 (ucl.ac.uk)

All informal enquiries can be sent to Prof JP Martinez-Barbera

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