International Cell Senescence Association

The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence. 

 

Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.

 

As such, the field of cellular senescence represents a multidisiplinary research topic.

For review articles on cell senescence click HERE

 

ICSA2020 #icsa2020osaka

ICSA2020 in Osaka[18575].jpg

**Postponed**

Please save the new dates:

June 7-10, 2021

click HERE for past conferences

More senescence conferences...

COMPARATIVE BIOLOGY OF AGING

15-19 Jun 2020 Roscoff (France)

***Postponed***

 

Cell Senescence News

 
https___cdn.evbuc.com_images_87977931_39

Featured Article

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

 

Gabriela Desdín-Micó, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabandé-Rodríguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cussó, Manuel Desco, Borja Ibañez, Arancha R. Gortazar, Pablo Fernández-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcamí, Francesc Baixauli,María Mittelbrunn

The effect of immunometabolism on age-associated diseases remains uncertain. In this work, we show that T cells with dysfunctional mitochondria owing to mitochondrial transcription factor A (TFAM) deficiency act as accelerators of senescence. In mice, these cells instigate multiple aging-related features, including metabolic, cognitive, physical, and cardiovascular alterations, which together result in premature death. T cell metabolic failure induces the accumulation of circulating cytokines, which resembles the chronic inflammation that is characteristic of aging (“inflammaging”). This cytokine storm itself acts as a systemic inducer of senescence. Blocking tumor necrosis factor–α signaling or preventing senescence with nicotinamide adenine dinucleotide precursors partially rescues premature aging in mice with Tfam-deficient T cells. Thus, T cells can regulate organismal fitness and life span, which highlights the importance of tight immunometabolic control in both aging and the onset of age-associated diseases.

kisspng-pdf-computer-icons-download-pdf-

To learn more about young ICSA (yICSA), click here!

 

About ICSA

President

Manuel Serrano, 

Institute for Research

and Biomedicine, Barcelona, 

Spain

Vice-President

Oliver Bischof

Institut Pasteur,

Paris, France

Treasurer

Sushma-Nagaraja Grellscheid, 

Durham University,

Durham, UK

Secretary

Romuald Binet,

 Ludwig Institute for Cancer Research, Oxford, UK

Website Manager

Dominick Burton,

Loughborough

University, UK

Steering Committee Members

Lars Zender

University Hospital Tübingen,

Tübingen, Germany

Manuel Collado,
Health Research Institute of Santiago de Compostela,

Santiago de Compostela, Spain

Cleo Bishop
Senior Lecturer
Blizard Institute

London, UK
 

Clemens Schmitt

Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German

Dorothy Bennett 

St George's,

University of London,

UK

Marco Demaria

Faculty of Medical Sciences

University of Groningen,

Netherlands

Andrea Maier

Royal Melbourne Hospital

University of Melbourne,

Australia

Gerardo Ferbeyre 

Département de biochimie
Faculté de Médecine
Université de Montréal

Learn More

Live Longer, Live Well

Telomeres and Cell Senescence

Researchers Extend Lifespan by as Much as 35 Percent in Mice

 
 

ICSA Membership

How to join ICSA?

The cost of registration for one year of ICSA membership is:

  • Standard - 50€

  • Student/Postdoc - 25€

To become a member, follow this link.

*** REGISTER NOW FOR 2020 ***