International Cell Senescence Association

The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence.

Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.

As such, the field of cellular senescence represents a multidisiplinary research topic.

For review articles on cell senescence click HERE

ICSA2020 #icsa2020osaka

http://www.icsa2020-osaka.jp

click HERE for past conferences

More senescence conferences...

COMPARATIVE BIOLOGY OF AGING

15-19 Jun 2020 Roscoff (France)

Cell Senescence News

Paper of the Month

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Vagisha Sharma, Luigi Ferrucci, Judith Campisi, Birgit Schilling

The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present the “SASP Atlas,” a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types. Each profile consists of hundreds of largely distinct proteins but also includes a subset of proteins elevated in all SASPs. Our analyses identify several candidate biomarkers of cellular senescence that overlap with aging markers in human plasma, including Growth/differentiation factor 15 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantly correlated with age in plasma from a human cohort, the Baltimore Longitudinal Study of Aging (BLSA). Our findings will facilitate the identification of proteins characteristic of senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus, and tissue of origin of senescent cells in vivo.

About ICSA

President

Manuel Serrano,

Institute for Research

and Biomedicine, Barcelona,

Spain

Vice-President

Oliver Bischof

Institut Pasteur,

Paris, France

Treasurer

Sushma-Nagaraja Grellscheid,

Durham University,

Durham, UK

Secretary

Romuald Binet,

Ludwig Institute for Cancer Research, Oxford, UK

Website Manager

Dominick Burton,

Loughborough

University, UK

Steering Committee Members

Lars Zender

University Hospital Tübingen,

Tübingen, Germany

Manuel Collado,
Health Research Institute of Santiago de Compostela,

Santiago de Compostela, Spain

Cleo Bishop
Senior Lecturer
Blizard Institute

London, UK

Clemens Schmitt

Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German

Dorothy Bennett

St George's,

University of London,

Marco Demaria

Faculty of Medical Sciences

University of Groningen,

Netherlands

Andrea Maier

Royal Melbourne Hospital

University of Melbourne,

Australia

Gerardo Ferbeyre

Département de biochimie
Faculté de Médecine
Université de Montréal

Learn More

Live Longer, Live Well

Telomeres and Cell Senescence

Researchers Extend Lifespan by as Much as 35 Percent in Mice

Continue...

ICSA Membership

How to join ICSA?

The cost of registration for one year of ICSA membership is:

Standard - 50€
Student/Postdoc - 25€

To become a member, follow this link.

*** REGISTER NOW FOR 2020 ***

International Cell Senescence Association