International Cell Senescence Association

The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence.

Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.

As such, the field of cellular senescence represents a multidisiplinary research topic.

For review articles on cell senescence click HERE

ICSA2020 #icsa2020osaka

http://www.icsa2020-osaka.jp

Postponed

Please save the new dates:

June 7-10, 2021

click HERE for past conferences

More senescence conferences...

COMPARATIVE BIOLOGY OF AGING

15-19 Jun 2020 Roscoff (France)

Postponed

Cell Senescence News

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Paper of the Month

Elimination of senescent cells by β-galactosidase targeted prodrug attenuates inflammation and restores physical function in aged mice

Yusheng Cai, Huanhuan Zhou, Yinhua Zhu, Qi Sun, Yin Ji, Anqi Xue, Yuting Wang, Wenhan Chen, Xiaojie Yu, Longteng Wang, Han Chen, Cheng Li, Tuoping Luo and Hongkui Deng

Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of senescent cells is expected to decrease chronic, low-grade inflammation and improve tissue repair capacity, thus attenuating the decline of physical function in aged organisms. However, selective and effective clearance of senescent cells of different cell types has proven challenging. Herein, we developed a prodrug strategy to design a new compound based on the increased activity of lysosomal β-galactosidase (β-gal), a primary characteristic of senescent cells. Our prodrug SSK1 is specifically activated by β-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types. In aged mice, our compound effectively cleared senescent cells in different tissues, decreased the senescence- and age-associated gene signatures, attenuated low-grade local and systemic inflammation, and restored physical function. Our results demonstrate that lysosomal β-gal can be effectively leveraged to selectively eliminate senescent cells, providing a novel strategy to develop anti-aging interventions.