International Cell Senescence Association

The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence. 


Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.


As such, the field of cellular senescence represents a multidisiplinary research topic.

For review articles on cell senescence click HERE


ICSA2020 #icsa2020osaka

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Please save the new dates:

December 12-15, 2021

click HERE for past conferences

More senescence conferences...


15-19 Jun 2020 Roscoff (France)



Cell Senescence News

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Members Featured Articles

The Jekyll and Hyde of Senescence in Cancer: TIMP1 Controls the Switch from Tumor-Controlling to Tumor-Promoting Senescence


Sabela Da Silva-Álvarez, Manuel Collado

Cellular senescence is a response with two faces in cancer: it restricts tumor proliferation, but it can also promote cancer progression and metastasis. In this issue of Cancer Cell, Guccini et al. uncover the role of TIMP1 in prostate cancer allowing a switch from tumor-controlling to tumor-promoting senescence.



Refers to:

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

Cancer Cell, Volume 39, Issue 1, 11 January 2021, Pages 68-82.e9

More ICSA members featured articles here


Paper of the Month

NAD+boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle


Mario Romani, Vincenzo Sorrentino, Chang-Myung Oh, Hao Li, Tanes Imamura de Lima, Hongbo Zhang, Minho Shong, and Johan Auwerx

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bio-informatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging anddiseases. Moreover, we show accumulation of amyloid-like deposits and mitochondrial dysfunction duringnatural aging in the body wall muscle ofC.elegans, in human primary myotubes, and in mouse skeletal mus-cle, partially phenocopying inclusion body myositis (IBM). Importantly, NAD+homeostasis is critical tocontrol age-associated muscle amyloidosis. Treatment of either aged N2 worms, a nematode model of am-yloid-beta muscle proteotoxicity, human aged myotubes, or old mice with the NAD+boosters nicotinamideriboside (NR) and olaparib (AZD) increases mitochondrial function and muscle homeostasis while attenuatingamyloid accumulation. Hence, our data reveal that age-related amyloidosis is a contributing factor to mito-chondrial dysfunction and that both are features of the aging muscle that can be ameliorated by NAD+meta-bolism-enhancing approaches, warranting further clinical studies.


To learn more about young ICSA (yICSA), click here!


About ICSA


Manuel Serrano, 

Institute for Research

and Biomedicine, Barcelona, 



Oliver Bischof

Institut Pasteur,

Paris, France


Sushma-Nagaraja Grellscheid, 

Durham University,

Durham, UK


Romuald Binet,

 Ludwig Institute for Cancer Research, Oxford, UK

Website Manager

Dominick Burton,


University, UK

Steering Committee Members

Lars Zender

University Hospital Tübingen,

Tübingen, Germany

Manuel Collado,
Health Research Institute of Santiago de Compostela,

Santiago de Compostela, Spain

Cleo Bishop
Senior Lecturer
Blizard Institute

London, UK

Clemens Schmitt

Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German

Dorothy Bennett 

St George's,

University of London,


Marco Demaria

Faculty of Medical Sciences

University of Groningen,


Andrea Maier

Royal Melbourne Hospital

University of Melbourne,


Gerardo Ferbeyre 

Département de biochimie
Faculté de Médecine
Université de Montréal

Learn More

Live Longer, Live Well

Telomeres and Cell Senescence

Researchers Extend Lifespan by as Much as 35 Percent in Mice


ICSA Membership

How to join ICSA?

The cost of registration for one year of ICSA membership is:

  • Standard - 50€

  • Student/Postdoc - 25€

To become a member, follow this link.

*** REGISTER NOW FOR 2021 ***


Access your personal page here.