International Cell Senescence Association
The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence.
Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.
As such, the field of cellular senescence represents a multidisiplinary research topic.
For review articles on cell senescence click HERE



ICSA2020 #icsa2020osaka
**Postponed**
Please save the new dates:
December 12-15, 2021
click HERE for past conferences
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Cell Senescence News
Members Featured Articles
The Jekyll and Hyde of Senescence in Cancer: TIMP1 Controls the Switch from Tumor-Controlling to Tumor-Promoting Senescence
Sabela Da Silva-Álvarez, Manuel Collado
Cellular senescence is a response with two faces in cancer: it restricts tumor proliferation, but it can also promote cancer progression and metastasis. In this issue of Cancer Cell, Guccini et al. uncover the role of TIMP1 in prostate cancer allowing a switch from tumor-controlling to tumor-promoting senescence.
Refers to:
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
Cancer Cell, Volume 39, Issue 1, 11 January 2021, Pages 68-82.e9

More ICSA members featured articles here
Paper of the Month
Reprogramming to recover youthful epigenetic information and restore vision
Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M. Hoffmann, Margarete M. Karg, Michael B. Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A. Rajman, George M. Church, Konrad Hochedlinger, Vadim N. Gladyshev, Steve Horvath, Morgan E. Levine, Meredith S. Gregory-Ksander, Bruce R. Ksander, Zhigang He & David A. Sinclair
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity. Changes to DNA methylation patterns over time form the basis of ageing clocks4, but whether older individuals retain the information needed to restore these patterns—and, if so, whether this could improve tissue function—is not known. Over time, the central nervous system (CNS) loses function and regenerative capacity. Using the eye as a model CNS tissue, here we show that ectopic expression of Oct4 (also known as Pou5f1), Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice. The beneficial effects of OSK-induced reprogramming in axon regeneration and vision require the DNA demethylases TET1 and TET2. These data indicate that mammalian tissues retain a record of youthful epigenetic information—encoded in part by DNA methylation—that can be accessed to improve tissue function and promote regeneration in vivo.
To learn more about young ICSA (yICSA), click here!
About ICSA

President
Manuel Serrano,
Institute for Research
and Biomedicine, Barcelona,
Spain
Vice-President
Oliver Bischof
Institut Pasteur,
Paris, France
Treasurer
Sushma-Nagaraja Grellscheid,
Durham University,
Durham, UK
Secretary
Romuald Binet,
Ludwig Institute for Cancer Research, Oxford, UK
Website Manager
Dominick Burton,
Loughborough
University, UK
Steering Committee Members
Lars Zender
University Hospital Tübingen,
Tübingen, Germany
Manuel Collado,
Health Research Institute of Santiago de Compostela,
Santiago de Compostela, Spain
Cleo Bishop
Senior Lecturer
Blizard Institute
London, UK
Clemens Schmitt
Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German
Dorothy Bennett
St George's,
University of London,
UK

Andrea Maier
Royal Melbourne Hospital
University of Melbourne,
Australia
Gerardo Ferbeyre
Département de biochimie
Faculté de Médecine
Université de Montréal
Learn More
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Telomeres and Cell Senescence
Researchers Extend Lifespan by as Much as 35 Percent in Mice