International Cell Senescence Association
The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence.
Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.
As such, the field of cellular senescence represents a multidisiplinary research topic.
For review articles on cell senescence click HERE
click HERE for past conferences
More senescence conferences...
Cell Senescence News
Paper of the Month
Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Vagisha Sharma, Luigi Ferrucci, Judith Campisi, Birgit Schilling
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present the “SASP Atlas,” a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types. Each profile consists of hundreds of largely distinct proteins but also includes a subset of proteins elevated in all SASPs. Our analyses identify several candidate biomarkers of cellular senescence that overlap with aging markers in human plasma, including Growth/differentiation factor 15 (GDF15), stanniocalcin 1 (STC1), and serine protease inhibitors (SERPINs), which significantly correlated with age in plasma from a human cohort, the Baltimore Longitudinal Study of Aging (BLSA). Our findings will facilitate the identification of proteins characteristic of senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus, and tissue of origin of senescent cells in vivo.
Institute for Research
and Biomedicine, Barcelona,
Ludwig Institute for Cancer Research, Oxford, UK
Steering Committee Members
University Hospital Tübingen,
Health Research Institute of Santiago de Compostela,
Santiago de Compostela, Spain
Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German
University of London,
University of Groningen,
Royal Melbourne Hospital
University of Melbourne,
Département de biochimie
Faculté de Médecine
Université de Montréal
Live Longer, Live Well
Telomeres and Cell Senescence
Researchers Extend Lifespan by as Much as 35 Percent in Mice
How to join ICSA?
The cost of registration for one year of ICSA membership is:
Standard - 50€
Student/Postdoc - 25€
To become a member, follow this link.
*** REGISTER NOW FOR 2020 ***