International Cell Senescence Association
The association aims to promote research, co-operation and exchange of information among all those interested in any aspect of cellular senescence.
Cellular senescence is a programmed state of stable cell cycle arrest that is accompanied by a complex phenotype. Senescent cells play a role in physiological processes such as tumour suppression, wound healing and embryonic development, whilst paradoxically they can contribute to ageing, cancer and age-related disease.
As such, the field of cellular senescence represents a multidisiplinary research topic.
For review articles on cell senescence click HERE
ICSA2020 #icsa2020osaka
![ICSA2020 in Osaka[18575].jpg](https://static.wixstatic.com/media/1b117e_7bfda9c2d1cf473398f607341cd31b5d~mv2_d_1241_1790_s_2.jpg/v1/fill/w_383,h_552,al_c,q_80,usm_0.66_1.00_0.01/ICSA2020%20in%20Osaka%5B18575%5D.jpg)
**Postponed**
Please save the new dates:
June 7-10, 2021
click HERE for past conferences
More senescence conferences...
Cell Senescence News
Featured Article
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
Gabriela Desdín-Micó, Gonzalo Soto-Heredero, Juan Francisco Aranda, Jorge Oller, Elisa Carrasco, Enrique Gabandé-Rodríguez, Eva Maria Blanco, Arantzazu Alfranca, Lorena Cussó, Manuel Desco, Borja Ibañez, Arancha R. Gortazar, Pablo Fernández-Marcos, Maria N. Navarro, Bruno Hernaez, Antonio Alcamí, Francesc Baixauli,María Mittelbrunn
The effect of immunometabolism on age-associated diseases remains uncertain. In this work, we show that T cells with dysfunctional mitochondria owing to mitochondrial transcription factor A (TFAM) deficiency act as accelerators of senescence. In mice, these cells instigate multiple aging-related features, including metabolic, cognitive, physical, and cardiovascular alterations, which together result in premature death. T cell metabolic failure induces the accumulation of circulating cytokines, which resembles the chronic inflammation that is characteristic of aging (“inflammaging”). This cytokine storm itself acts as a systemic inducer of senescence. Blocking tumor necrosis factor–α signaling or preventing senescence with nicotinamide adenine dinucleotide precursors partially rescues premature aging in mice with Tfam-deficient T cells. Thus, T cells can regulate organismal fitness and life span, which highlights the importance of tight immunometabolic control in both aging and the onset of age-associated diseases.
To learn more about young ICSA (yICSA), click here!
About ICSA
President
Manuel Serrano,
Institute for Research
and Biomedicine, Barcelona,
Spain
Vice-President
Oliver Bischof
Institut Pasteur,
Paris, France
Treasurer
Sushma-Nagaraja Grellscheid,
Durham University,
Durham, UK
Secretary
Romuald Binet,
Ludwig Institute for Cancer Research, Oxford, UK
Website Manager
Dominick Burton,
Loughborough
University, UK
Steering Committee Members
Lars Zender
University Hospital Tübingen,
Tübingen, Germany
Manuel Collado,
Health Research Institute of Santiago de Compostela,
Santiago de Compostela, Spain
Cleo Bishop
Senior Lecturer
Blizard Institute
London, UK
Clemens Schmitt
Charité-Universitätsmedizin Berlin (CVK), and Max-Delbrück-Center for Molecular Medicine, Berlin, German
Dorothy Bennett
St George's,
University of London,
UK
Andrea Maier
Royal Melbourne Hospital
University of Melbourne,
Australia
Gerardo Ferbeyre
Département de biochimie
Faculté de Médecine
Université de Montréal
Learn More
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