Mitochondrial metabolism and epigenetic crosstalk drive SASP Martini, H. et al., Nature 2026 Brief Summary How do mitochondria drive inflammation in senescent cells? In a new study published in Nature, led by João Passos and Peter Adams, with Helene Martini as first author, the team uncovered a metabolic-epigenetic pathway controlling the senescence-associated secretory phenotype (SASP). Previous work by the Passos Lab showed that senescent mitochondria release mtDNA into the cytosol,...

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging Opezzo, A. et al., Nature Aging 2026 Brief Summary from the authors: What if some consequences of aging are driven not by the damage itself, but by the alarm signals our cells generate in response to it? More than 20 years ago, we discovered that dysfunctional telomeres activate a DNA damage response (DDR), driving cellular senescence and inflammation. One key...

Deadline 31st of August! 5th ICSA DEI Travel Fellowship for ICSA2026 Deadline: 31st August 2026 Who can apply: Our DEI Travel Fellowship is open to paid ICSA Members who self-identify with at least one facet of our Diversity Wheel. Other eligibility criteria apply. The award: up to 1000 EUR towards travel and accommodation to attend the conference, free registration to ICSA2026 and a ticket to the Gala Dinner. How to apply: Full details on eligibility, the funding, the timeline, and...